Journal article
Benefit of Radiotherapy in Extraskeletal Myxoid Chondrosarcoma A Propensity Score Weighted Population-based Analysis of the SEER Database
American journal of clinical oncology, v 41(7), pp 674-680
01 Jul 2018
PMID: 27819877
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Objectives: Extraskeletal myxoid chondrosarcoma (EMC) is a rare malignancy for which the role of radiotherapy is not well-defined. We examine the effect of external beam radiotherapy (EBRT) on cancer-specific survival (CSS) for patients with localized EMC, in a propensity score weighted, population-based analysis.
Materials and Methods: The Surveillance, Epidemiology, and End Results database (1973 to 2012) was queried for cases of localized EMC arising from soft connective tissues of the trunk and extremities treated with surgery and/or EBRT. Inverse probability treatment weighting was utilized, with survival analysis by weighted Cox regression and Kaplan-Meier analysis with log-rank testing. The primary endpoint was CSS.
Results: One hundred seventy-two patients were identified, diagnosed from 2004 to 2012. Ninety-four percent and 32% of 156 assessable patients underwent surgery and EBRT, respectively. By inverse probability treatment weighting, balancing covariates of age group, sex, race, grade, T stage, N stage, receipt of surgery, and anatomic site, we observed CSS of 97% versus 85% and 94% versus 85% in patients receiving EBRT versus no EBRT, at 3 and 5 years, respectively, at median follow-up of 33 months, P = 0.01. A trend toward an overall survival benefit associated with EBRT was noted, P = 0.06. Further adjusting for type of resection performed, CSS benefit persisted, 97% versus 85% at 3 years and 94% versus 85% at 5 years, P = 0.02, with trend toward an overall survival benefit, P = 0.08.
Conclusions: The receipt of EBRT is associated with a CSS benefit m localized EMC Aggressive local therapy, including EBRT, should be considered m these patients.
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Details
- Title
- Benefit of Radiotherapy in Extraskeletal Myxoid Chondrosarcoma A Propensity Score Weighted Population-based Analysis of the SEER Database
- Creators
- Eric J. Kemmerer - Departments of Radiation Oncology.Elizabeth Gleeson - Drexel UniversityJaganmohan Poli - Departments of Radiation Oncology.Robert T. Ownbey - Drexel Univ, Coll Med, Dept Surg, Philadelphia, PA 19104 USALuther W. Brady - Drexel UniversityWilbur B. Bowne - Drexel University
- Publication Details
- American journal of clinical oncology, v 41(7), pp 674-680
- Publisher
- Lippincott Williams & Wilkins
- Number of pages
- 7
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Radiation Oncology (and Nuclear Medicine)
- Web of Science ID
- WOS:000441386500010
- Scopus ID
- 2-s2.0-84994682236
- Other Identifier
- 991019168804904721
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InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Web of Science research areas
- Oncology