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Journal article
Biceps Detachment Decreases Joint Damage in a Rotator Cuff Tear Rat Model
Clinical orthopaedics and related research, v 472(8), pp 2404-2412
01 Aug 2014
PMID: 24326594
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Pathology in the long head of the biceps tendon often occurs in patients with rotator cuff tears. Arthroscopic tenotomy is the most common treatment. However, the role of the long head of the biceps at the shoulder and the consequences of surgical detachment on the remaining shoulder structures remain unknown.
We hypothesized that detachment of the long head of the biceps, in the presence of supraspinatus and infraspinatus tears, would decrease shoulder function and decrease mechanical and histologic properties of both the subscapularis tendon and the glenoid articular cartilage.
We detached the supraspinatus and infraspinatus or the supraspinatus, infraspinatus, and long head of the biceps after 4 weeks of overuse in a rat model. Animals were gradually returned to overuse activity after detachment. At 8 weeks, the subscapularis and glenoid cartilage biomechanical and histologic properties were evaluated and compared.
The group with the supraspinatus, infraspinatus, and long head of the biceps detached had greater medial force and decreased change in propulsion, braking, and vertical force. This group also had an increased upper and lower subscapularis modulus but without any differences in glenoid cartilage modulus. Finally, this group had a significantly lower cell density in both the upper and lower subscapularis tendons, although cartilage histology was not different.
Detachment of the long head of the biceps tendon in the presence of a posterior-superior cuff tear resulted in improved shoulder function and less joint damage in this animal model.
This study provides evidence in an animal model that supports the use of tenotomy for the management of long head of the biceps pathology in the presence of a two-tendon cuff tear. However, long-term clinical trials are required.
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Details
- Title
- Biceps Detachment Decreases Joint Damage in a Rotator Cuff Tear Rat Model
- Creators
- Stephen J. Thomas - University of PennsylvaniaKatherine E. Reuther - University of PennsylvaniaJennica J. Tucker - University of PennsylvaniaJoseph J. Sarver - University of PennsylvaniaSarah M. Yannascoli - University of PennsylvaniaAdam C. Caro - University of PennsylvaniaPramod B. Voleti - University of PennsylvaniaSarah I. Rooney - University of PennsylvaniaDavid L. Glaser - University of PennsylvaniaLouis J. Soslowsky - University of Pennsylvania
- Publication Details
- Clinical orthopaedics and related research, v 472(8), pp 2404-2412
- Publisher
- Lippincott Williams & Wilkins
- Number of pages
- 9
- Grant note
- R01AR056658 / NIH/NIAMS (Bethesda, MD, USA) R25OD010986 / OFFICE OF THE DIRECTOR, NATIONAL INSTITUTES OF HEALTH; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA P30 AR050950 / Penn Center for Musculoskeletal Disorders (Philadelphia, PA, USA) (NIH Grant) P30AR050950 / NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Arthritis & Musculoskeletal & Skin Diseases (NIAMS)
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- School of Biomedical Engineering, Science, and Health Systems
- Web of Science ID
- WOS:000338997100017
- Scopus ID
- 2-s2.0-84904121098
- Other Identifier
- 991019176804304721
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Data related to this publication, from InCites Benchmarking & Analytics tool:
- Web of Science research areas
- Orthopedics
- Surgery