Journal article
Binding of CDK9 to TRAF2
Journal of cellular biochemistry, v 71(4), pp 467-478
15 Dec 1998
PMID: 9827693
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
CDK9 has been recently shown to have increased kinase activity in differentiated cells in culture and a differentiated tissue‐specific expression in the developing mouse. In order to identify factors that contribute to CDK9's differentiation‐specific function, we screened a mouse embryonic library in the yeast two‐hybrid system and found a tumor necrosis factor signal transducer, TRAF2, to be an interacting protein. CDK9 interacts with a conserved domain in the TRAF‐C region of TRAF2, a motif that is known to bind other kinases involved in TRAF‐mediated signaling. Endogenous interaction between the two proteins appears to be specific to differentiated tissue. TRAF2‐mediated signaling may incorporate additional kinases to signal cell survival in myotubes, a cell type that is severely affected in TRAF2 knockout mice. J. Cell. Biochem. 71:467–478, 1998. © 1998 Wiley‐Liss, Inc.
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Details
- Title
- Binding of CDK9 to TRAF2
- Creators
- Timothy K MacLachlanNianli SangAntonio De LucaPier Lorenzo PuriMassimo LevreroAntonio Giordano
- Publication Details
- Journal of cellular biochemistry, v 71(4), pp 467-478
- Publisher
- Wiley Subscription Services, Inc., A Wiley Company; Hoboken
- Number of pages
- 12
- Grant note
- NIH (training grant 1‐T32‐HL07780)
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Biology
- Web of Science ID
- WOS:000077007000002
- Scopus ID
- 2-s2.0-0032534580
- Other Identifier
- 991014877885904721
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- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Biochemistry & Molecular Biology
- Cell Biology