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Journal article
Bioactive Polyphenolic Compounds Showing Strong Antiviral Activities against Severe Acute Respiratory Syndrome Coronavirus 2
Pathogens (Basel), v 10(6), 758
15 Jun 2021
PMID: 34203977
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Until now, there has been no direct evidence of the effectiveness of repurposed FDA-approved drugs against Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) infections. Although curcumin, hesperidin, and quercetin have broad spectra of pharmacological properties, their antiviral activities against SARS-CoV-2 remain unclear. Our study aimed to assess the in vitro antiviral activities of curcumin, hesperidin, and quercetin against SARS-CoV-2 compared to hydroxychloroquine and determine their mode of action. In Vero E6 cells, these compounds significantly inhibited virus replication, mainly as virucidal agents primarily indicating their potential activity at the early stage of viral infection. To investigate the mechanism of action of the tested compounds, molecular docking studies were carried out against both SARS-CoV-2 spike (S) and main protease (Mpro) receptors. Collectively, the obtained in silico and in vitro findings suggest that the compounds could be promising SARS-CoV-2 Mpro inhibitors. We recommend further preclinical and clinical studies on the studied compounds to find a potential therapeutic targeting COVID-19 in the near future.
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Details
- Title
- Bioactive Polyphenolic Compounds Showing Strong Antiviral Activities against Severe Acute Respiratory Syndrome Coronavirus 2
- Creators
- Ahmed Kandeil - National Research CentreAhmed Mostafa - National Research CentreOmnia Kutkat - National Research CentreYassmin Moatasim - National Research CentreAhmed A. Al-Karmalawy - Horus University-Egypt (Egypt, New Damietta)Adel A. Rashad - Drexel UniversityAhmed E. Kayed - National Research CentreAzza E. Kayed - Egyptian Atomic Energy AuthorityRabeh El-Shesheny - National Research CentreGhazi Kayali - The University of Texas Health Science Center at HoustonMohamed A. Ali - National Research Centre
- Publication Details
- Pathogens (Basel), v 10(6), 758
- Publisher
- MDPI
- Number of pages
- 17
- Grant note
- HHSN272201400006C / National Institute of Allergy and Infectious Diseases, National Institutes of Health, US Department of Health and Human Services; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Allergy & Infectious Diseases (NIAID); NIH National Institute of Neurological Disorders & Stroke (NINDS) 7303 / Egyptian Academy of Scientific Research AMP; Technology (ASRT) within "Apply your idea" program
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Biochemistry and Molecular Biology; Microbiology and Immunology
- Web of Science ID
- WOS:000666167800001
- Scopus ID
- 2-s2.0-85108778358
- Other Identifier
- 991020172708104721
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- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Microbiology