Journal article
Biocompatibility and biodegradation studies of PCL/β-TCP bone tissue scaffold fabricated by structural porogen method
Journal of materials science. Materials in medicine, v 23(9), pp 2217-2226
Sep 2012
PMID: 22669285
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Three-dimensional printer (3DP) (Z-Corp) is a solid freeform fabrication system capable of generating sub-millimeter physical features required for tissue engineering scaffolds. By using plaster composite materials, 3DP can fabricate a universal porogen which can be injected with a wide range of high melting temperature biomaterials. Here we report results toward the manufacture of either pure polycaprolactone (PCL) or homogeneous composites of 90/10 or 80/20 (w/w) PCL/beta-tricalcium phosphate (β-TCP) by injection molding into plaster composite porogens fabricated by 3DP. The resolution of printed plaster porogens and produced scaffolds was studied by scanning electron microscopy. Cytotoxicity test on scaffold extracts and biocompatibility test on the scaffolds as a matrix supporting murine osteoblast (7F2) and endothelial hybridoma (EAhy 926) cells growth for up to 4 days showed that the porogens removal process had only negligible effects on cell proliferation. The biodegradation tests of pure PCL and PCL/β-TCP composites were performed in DMEM with 10 % (v/v) FBS for up to 6 weeks. The PCL/β-TCP composites show faster degradation rate than that of pure PCL due to the addition of β-TCP, and the strength of 80/20 PCL/β-TCP composite is still suitable for human cancellous bone healing support after 6 weeks degradation. Combining precisely controlled porogen fabrication structure, good biocompatibility, and suitable mechanical properties after biodegradation, PCL/β-TCP scaffolds fabricated by 3DP porogen method provide essential capability for bone tissue engineering.
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Details
- Title
- Biocompatibility and biodegradation studies of PCL/β-TCP bone tissue scaffold fabricated by structural porogen method
- Creators
- Lin Lu - Department of Mechanical Engineering and Mechanics Drexel University 3121 Chestnut St. Philadelphia PA 19104 USAQingwei Zhang - Department of Mechanical Engineering and Mechanics Drexel University 3121 Chestnut St. Philadelphia PA 19104 USADavid Wootton - Mechanical Engineering Cooper Union 41 Cooper Square New York NY 10003 USARichard Chiou - Department of Mechanical Engineering and Mechanics Drexel University 3121 Chestnut St. Philadelphia PA 19104 USADichen Li - School of Mechanical Engineering Xi’an Jiaotong University Xi’an ChinaBingheng Lu - School of Mechanical Engineering Xi’an Jiaotong University Xi’an ChinaPeter Lelkes - Department of Bioengineering Temple University Philadelphia PA 19122 USAJack Zhou - Department of Mechanical Engineering and Mechanics Drexel University 3121 Chestnut St. Philadelphia PA 19104 USA
- Publication Details
- Journal of materials science. Materials in medicine, v 23(9), pp 2217-2226
- Publisher
- Springer US; Boston
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Mechanical Engineering and Mechanics
- Web of Science ID
- WOS:000308242000017
- Scopus ID
- 2-s2.0-84867097728
- Other Identifier
- 991014877850504721
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- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Engineering, Biomedical
- Materials Science, Biomaterials