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Journal article
Bioenergetic variation is related to autism symptomatology
Metabolic brain disease, v 32(6), pp 2021-2031
Dec 2017
PMID: 28852932
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Autism spectrum disorder (ASD) has been associated with mitochondrial dysfunction but few studies have examined the relationship between mitochondrial function and ASD symptoms. We measured Complex I and IV and citrate synthase activities in 76 children with ASD who were not receiving vitamin supplementation or medication. We also measured language using the Preschool Language Scales or Clinical Evaluation of Language Fundamentals, adaptive behavior using the Vineland Adaptive Behavioral Scale, social function using the Social Responsiveness Scale and behavior using Aberrant Behavior Checklist, Childhood Behavior Checklist and the Ohio Autism Clinical Impression Scale. Children with ASD demonstrated significantly greater variation in mitochondrial activity compared to controls with more than expected ASD children having enzyme activity outside of the normal range for Citrate Synthase (24%), Complex I (39%) and Complex IV (11%). Poorer adaptive skills were associated with Complex IV activity lower or higher than average and lower Complex I activity. Poorer social function and behavior was associated with relatively higher Citrate Synthase activity. Similar to previous studies we find both mitochondrial underactivity and overactivity in ASD. This study confirms an expanded variation in mitochondrial activity in ASD and demonstrates, for the first time, that such variations are related to ASD symptoms.
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Details
- Title
- Bioenergetic variation is related to autism symptomatology
- Creators
- Leanna Delhey - Arkansas Children's HospitalEkim Nur Kilinc - University of Arkansas for Medical SciencesLi Yin - West China Hospital of Sichuan UniversityJohn Slattery - University of Arkansas for Medical SciencesMarie Tippett - University of Arkansas for Medical SciencesRebecca Wynne - University of Arkansas for Medical SciencesShannon Rose - University of Arkansas for Medical SciencesStephen Kahler - University of Arkansas for Medical SciencesShirish Damle - St. Christopher's Hospital for ChildrenAgustin Legido - St. Christopher's Hospital for ChildrenMichael J Goldenthal - St. Christopher's Hospital for ChildrenRichard E Frye - University of Arkansas for Medical Sciences
- Publication Details
- Metabolic brain disease, v 32(6), pp 2021-2031
- Publisher
- Springer Nature
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Pediatrics; School of Biomedical Engineering, Science, and Health Systems
- Web of Science ID
- WOS:000415225800027
- Scopus ID
- 2-s2.0-85028754144
- Other Identifier
- 991019168407104721
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- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Endocrinology & Metabolism
- Neurosciences