Logo image
Bioenergetic variation is related to autism symptomatology
Journal article   Open access   Peer reviewed

Bioenergetic variation is related to autism symptomatology

Leanna Delhey, Ekim Nur Kilinc, Li Yin, John Slattery, Marie Tippett, Rebecca Wynne, Shannon Rose, Stephen Kahler, Shirish Damle, Agustin Legido, …
Metabolic brain disease, v 32(6), pp 2021-2031
Dec 2017
PMID: 28852932
url
https://doi.org/10.1007/s11011-017-0087-0View
Published, Version of Record (VoR)CC BY V4.0 Open

Abstract

Autism Spectrum Disorder - diagnosis Autism Spectrum Disorder - metabolism Autism Spectrum Disorder - psychology Child Child, Preschool Citrate (si)-Synthase - metabolism Cognition - physiology Electron Transport Complex I - metabolism Electron Transport Complex IV - metabolism Energy Metabolism Female Humans Male Social Skills Symptom Assessment
Autism spectrum disorder (ASD) has been associated with mitochondrial dysfunction but few studies have examined the relationship between mitochondrial function and ASD symptoms. We measured Complex I and IV and citrate synthase activities in 76 children with ASD who were not receiving vitamin supplementation or medication. We also measured language using the Preschool Language Scales or Clinical Evaluation of Language Fundamentals, adaptive behavior using the Vineland Adaptive Behavioral Scale, social function using the Social Responsiveness Scale and behavior using Aberrant Behavior Checklist, Childhood Behavior Checklist and the Ohio Autism Clinical Impression Scale. Children with ASD demonstrated significantly greater variation in mitochondrial activity compared to controls with more than expected ASD children having enzyme activity outside of the normal range for Citrate Synthase (24%), Complex I (39%) and Complex IV (11%). Poorer adaptive skills were associated with Complex IV activity lower or higher than average and lower Complex I activity. Poorer social function and behavior was associated with relatively higher Citrate Synthase activity. Similar to previous studies we find both mitochondrial underactivity and overactivity in ASD. This study confirms an expanded variation in mitochondrial activity in ASD and demonstrates, for the first time, that such variations are related to ASD symptoms.

Metrics

13 Record Views
25 citations in Scopus

Details

UN Sustainable Development Goals (SDGs)

This publication has contributed to the advancement of the following goals:

#3 Good Health and Well-Being

InCites Highlights

Data related to this publication, from InCites Benchmarking & Analytics tool:

Collaboration types
Domestic collaboration
International collaboration
Web of Science research areas
Endocrinology & Metabolism
Neurosciences
Logo image