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Journal article
Bioengineered Stromal Cell-Derived Factor-1α Analogue Delivered as an Angiogenic Therapy Significantly Restores Viscoelastic Material Properties of Infarcted Cardiac Muscle
Journal of biomechanical engineering, v 136(8), pp 0845011-0845015
02 Jun 2014
PMID: 24860865
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Ischemic heart disease is a major health problem worldwide, and current therapies fail to address microrevascularization. Previously, our group demonstrated that the sustained release of novel engineered stromal cell-derived factor 1-α analogue (ESA) limits infarct spreading, collagen deposition, improves cardiac function by promoting angiogenesis in the region surrounding the infarct, and restores the tensile properties of infarcted myocardium. In this study, using a well-established rat model of ischemic cardiomyopathy, we describe a novel and innovative method for analyzing the viscoelastic properties of infarcted myocardium. Our results demonstrate that, compared with a saline control group, animals treated with ESA have significantly improved myocardial relaxation rates, while reducing the transition strain, leading to restoration of left ventricular mechanics.
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Details
- Title
- Bioengineered Stromal Cell-Derived Factor-1α Analogue Delivered as an Angiogenic Therapy Significantly Restores Viscoelastic Material Properties of Infarcted Cardiac Muscle
- Creators
- Alen Trubelja - University of PennsylvaniaJohn W. MacArthur - University of PennsylvaniaJoseph J. Sarver - Drexel UniversityJeffrey E. Cohen - Stanford UniversityGeorge Hung - University of PennsylvaniaYasuhiro Shudo - Stanford UniversityAlexander S. Fairman - University of PennsylvaniaJay Patel - Stanford UniversityBryan B. Edwards - Stanford UniversityScott M. Damrauer - University of PennsylvaniaWilliam Hiesinger - University of PennsylvaniaPavan Atluri - University of PennsylvaniaY. Joseph Woo - Department of Cardiothoracic Surgery, , e-mail:
- Publication Details
- Journal of biomechanical engineering, v 136(8), pp 0845011-0845015
- Publisher
- American Society of Mechanical Engineers
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- School of Biomedical Engineering, Science, and Health Systems
- Web of Science ID
- WOS:000338507000012
- Scopus ID
- 2-s2.0-84901954100
- Other Identifier
- 991019168860904721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Biophysics
- Engineering, Biomedical