Files and links (1)
Accepted (AM)CC BY-NC-ND V4.0, Open
Journal article
Biofabrication strategies for creating microvascular complexity
Biofabrication, Vol.11(3), pp.032001/1-032001/23
18 Apr 2019
PMID: 30743247
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Design and fabrication of effective biomimetic vasculatures constitutes a relevant and yet unsolved challenge, lying at the heart of tissue repair and regeneration strategies. Even if cell growth is achieved in 3D tissue scaffolds or advanced implants, tissue viability inevitably requires vascularization, as diffusion can only transport nutrients and eliminate debris within a few hundred microns. This engineered vasculature may need to mimic the intricate branching geometry of native microvasculature, referred to herein as vascular complexity, to efficiently deliver blood and recreate critical interactions between the vascular and perivascular cells as well as parenchymal tissues. This review first describes the importance of vascular complexity in labs- and organs-on-chips, the biomechanical and biochemical signals needed to create and maintain a complex vasculature, and the limitations of current 2D, 2.5D, and 3D culture systems in recreating vascular complexity. We then critically review available strategies for design and biofabrication of complex vasculatures in cell culture platforms, labs- and organs-on-chips, and tissue engineering scaffolds, highlighting their advantages and disadvantages. Finally, challenges and future directions are outlined with the hope of inspiring researchers to create the reliable, efficient and sustainable tools needed for design and biofabrication of complex vasculatures.
Metrics
4 Record Views
Details
- Title
- Biofabrication strategies for creating microvascular complexity
- Creators
- Alisa Morss Clyne - Drexel University Vascular Kinetics Laboratory, Mechanical Engineering & Mechanics, 3141 Chestnut Street, Philadelphia, PA 19104, United States of AmericaSwathi Swaminathan - Drexel UniversityAndrés Díaz Lantada - Universidad Politécnica de Madrid Product Development Lab, Mechanical Engineering Department, c/JoséGutiérrez Abascal 2, E-28006, Madrid, Spain
- Publication Details
- Biofabrication, Vol.11(3), pp.032001/1-032001/23
- Publisher
- IOP Publishing
- Number of pages
- 23
- Grant note
- 1 R01 HL140239-01 / National Heart, Lung, and Blood Institute (https://doi.org/10.13039/100000050)
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Biology
- Identifiers
- 991019167687704721
UN Sustainable Development Goals (SDGs)
This output has contributed to the advancement of the following goals:
InCites Highlights
These are selected metrics from InCites Benchmarking & Analytics tool, related to this output
- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Engineering, Biomedical
- Materials Science, Biomaterials