Journal article
Biofilm-related infections of cerebrospinal fluid shunts
Clinical microbiology and infection, v 12(4), pp 331-337
Apr 2006
PMID: 16524409
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Cerebrospinal fluid (CSF) shunts carry a high risk of complications. Infections represent a major cause ofshunt failure. Diagnosis and therapy of such infections are complicated by the formation of bacterial biofilms attached to shunt surfaces. This study correlated the pathophysiology and clinical course of biofilm infections with microscopical findings on the respective shunts. Surface irregularities, an important risk-factor for shunt colonisation with bacteria, were found to increase over time because of silicone degradation. Scanning electron-microscopy (SEM) documented residual biological material (dead biofilm), which can further promote extant bacterial adhesion, on newly manufactured shunts. Clinical course and SEM both documented bacterial dissemination against CSF flow and the monodirectional valve. In all cases, biofilms grew on both the inner and outer surfaces of the shunts. Microscopy and conventional culture detected all bacterial shunt infections. Analyses of 16S rDNA sequences using conserved primers identified bacteria in only one of three cases, probably because of previous formalin fixation of the samples.
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Details
- Title
- Biofilm-related infections of cerebrospinal fluid shunts
- Creators
- C.A Fux - Center for Biofilm Engineering, Montana State University, Bozeman, USAM Quigley - Department of Neurosurgery, Allegheny General Hospital, Pittsburgh, USAA.M Worel - Department of Pediatric Surgery, Spitalzentrum Biel, Biel, SwitzerlandC Post - Center for Genomic Sciences, Allegheny-Singer Research Institute, Pittsburgh, USAS Zimmerli - Institute for Infectious Diseases, University of Bern, Bern, SwitzerlandG Ehrlich - Center for Genomic Sciences, Allegheny-Singer Research Institute, Pittsburgh, USAR.H Veeh - Center for Biofilm Engineering, Montana State University, Bozeman, USA
- Publication Details
- Clinical microbiology and infection, v 12(4), pp 331-337
- Publisher
- Elsevier
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Microbiology and Immunology
- Web of Science ID
- WOS:000235661400006
- Scopus ID
- 2-s2.0-33644755610
- Other Identifier
- 991014877878604721
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- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Infectious Diseases
- Microbiology