Journal article
Bioinspired nanotopographical design of drug delivery systems
Nature reviews bioengineering, v 1(2), pp 139-152
01 Feb 2023
Abstract
Effective drug delivery is important in the treatment of various biomedical conditions, ranging from autoimmune disorders to cancer and bacterial infections. Nanostructured systems can help to overcome challenges to efficient drug delivery such as poor drug distribution, inefficient penetration across biological barriers and off-target effects. The bioinspired nanotopography of drug carrier surfaces provides a physical cue to modulate their interaction with biological systems. In this Review, we discuss how naturally occurring nanotopographical systems can inspire the design of biomaterials for drug delivery. We highlight nanoscale surface modifications of drug carriers and fabrication strategies, followed by a discussion about nanotopographical biointerfaces to regulate biological functions. Key bioinspired nanotopographical functionalities include bio-adhesion, barrier remodelling, drug uptake and subcellular trafficking, cellular signalling and modulation, and antimicrobial interfaces. Finally, we provide an outlook on the future of nanotopographical applications in drug delivery, with a focus on key challenges and exciting opportunities from bench to bedside.
Three-dimensional nanotopography plays a key role in the interaction of nanoscale drug delivery systems and biological components. This Review discusses bioinspired nanotopographies that can improve muco-adhesion and cyto-adhesion, drug uptake and trafficking, barrier remodelling, cellular modulation and antimicrobial activities of various drug delivery platforms.
Key points
Three-dimensional nanotopography is ubiquitous in nature (for example, spiky pollen microparticles and nanopillars on cicada wings), impacting the biointerface of surfaces and biological components.
Bioinspired nanotopography can be engineered for every major drug carrier class, including thin films, patches, implants, stents and discrete particle drug carriers.
Bioinspired nanotopography can improve bio-adhesion, drug uptake and trafficking, epithelial barrier remodelling, cell signalling, and modulation and can be applied to implement antimicrobial effects.
Nanotopographical drug carriers can be applied to treat a variety of diseases and conditions, including diabetes, cancer, cardiovascular disease, fractures, wounds and microbial infections, improving biomedical outcomes in preclinical studies compared to drug delivery approaches without nanotopography.
Advances in nanotopographical fabrication, cell–material interface characterization, and in vitro and in vivo disease models will be key to promoting the clinical translation of nanotopographical platforms.
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Details
- Title
- Bioinspired nanotopographical design of drug delivery systems
- Creators
- Joel A. Finbloom - University of California, San FranciscoCindy Huynh - University of California, San FranciscoXiao Huang - University of California, San FranciscoTejal A. Desai - University of California, San Francisco
- Publication Details
- Nature reviews bioengineering, v 1(2), pp 139-152
- Publisher
- Nature Publishing Group
- Number of pages
- 14
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- School of Biomedical Engineering, Science, and Health Systems
- Web of Science ID
- WOS:001390122800001
- Other Identifier
- 991022130761004721
InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Web of Science research areas
- Engineering, Biomedical
- Materials Science, Biomaterials