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Biological characterization of Sorona polymer from corn-derived 1,3-propanediol
Journal article   Peer reviewed

Biological characterization of Sorona polymer from corn-derived 1,3-propanediol

Sujata K Bhatia and Joseph V Kurian
Biotechnology letters, v 30(4), pp 619-623
01 Apr 2008
DOI: https://doi.org/10.1007/s10529-007-9607-z
PMID: 18040602
Featured in Collection :   UN Sustainable Development Goals @ Drexel

Abstract

3T3 Cells Animals Biocompatible Materials - chemistry Biocompatible Materials - pharmacology Cell Line Cell Survival - drug effects Fibroblasts - cytology Fibroblasts - drug effects Fibroblasts - metabolism Macrophages - cytology Macrophages - drug effects Macrophages - metabolism Mice Models, Molecular Molecular Structure Polymers - chemistry Polymers - pharmacology Propylene Glycols - chemistry Tumor Necrosis Factor-alpha - metabolism Zea mays - chemistry
The Sorona family of polymers, based on corn-derived 1,3-propanediol, have recently been developed as novel bio-based materials for use in plastics, films, and fibers. In the present study, Sorona polymers were investigated for their effects on cell survival and inflammatory cell activation using in vitro mouse cell cultures. Cytotoxicity of Sorona polymers was evaluated by placing material samples in direct contact with 3T3 fibroblast cells. Both Sorona plastic and Sorona films were non-cytotoxic to fibroblasts. The inflammatory potential of Sorona samples was evaluated by exposing J774 macrophage cells to material samples, and measuring TNF-alpha release from macrophages. Sorona plastic and Sorona films did not elicit inflammatory TNF-alpha release from macrophages. These results indicate that Sorona polymers are non-cytotoxic and non-inflammatory. While the 1,3-propanediol component of Sorona 3GT is manufactured in a bacterial fermentation process, the absence of an inflammatory response to Sorona film and Sorona plastic is highly encouraging. The results are significant for the design of materials that utilize bio-based polymers.

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26 citations in Web of Science
29 citations in Scopus

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#12 Responsible Consumption & Production

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Web of Science research areas
Biotechnology & Applied Microbiology
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