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Biological response modifier-mediated resistance to herpesvirus infections requires induction of α/β interferon
Journal article   Peer reviewed

Biological response modifier-mediated resistance to herpesvirus infections requires induction of α/β interferon

Steven C. Kunder, Kathleen M. Kelly, Page S. Morahan and Kevin M Kelly
Antiviral research, v 21(2), pp 129-139
1993
DOI: https://doi.org/10.1016/0166-3542(93)90049-O
PMID: 7687839
Featured in Collection :   UN Sustainable Development Goals @ Drexel

Abstract

Biological response modifier CL246,738 HSV-2 Interferon MCMV pICLC
The role of interferon α/β (IFN) induction by the immunomodulators pICLC and CL246,738 was investigated in CD-1 mice infected with murine cytomegalovirus (MCMV) or herpes simplex virus type 2 (HSV-2). Mice were treated with either normal sheep serum or anti-α/β IFN antiserum, inoculated with the immunomodulators, and infected with virus. Because anti-IFN treatment also decreased natural resistance to HSV-2 and MCMV, two viral challenge doses were used to ensure that the mice with control serum or anti-IFN antiserum received biologically equivalent infections. Antiviral protection of pICLC and CL246,738 against HSV-2 infection was completely abrogated by treatment with anti-α/β interferon antiserum. Mice treated with pICLC also lost antiviral protection against MCMV when interferon α/β was depleted. These results indicate that induction of interferon α/β appears to be a major mechanism for both natural resistance and pICLC-induced antiviral protection against MCMV and HSV-2 herpesvirus infections.

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15 citations in Web of Science
16 citations in Scopus

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Web of Science research areas
Pharmacology & Pharmacy
Virology
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