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Accepted (AM)Open Access (License Unspecified), Open
Journal article
Biomarkers as MEDiators of racial disparities in risk factors (BioMedioR): Rationale, study design, and statistical considerations
Annals of epidemiology, v 66, pp 13-19
Feb 2022
PMID: 34742867
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Relative to White adults, Black adults have a substantially higher prevalence of hypertension and diabetes, both key risk factors for stroke, cardiovascular disease, cognitive impairment, and dementia. Blood biomarkers have shown promise in identifying contributors to racial disparities in many chronic diseases.
We outline the study design and related statistical considerations for a nested cohort study, the Biomarker Mediators of Racial Disparities in Risk Factors (BioMedioR) study, within the 30,239-person biracial REasons for Geographic And Racial Differences in Stroke (REGARDS) study (2003-present). Selected biomarkers will be assessed for contributions to racial disparities in risk factor development over median 9.4 years of follow-up, with initial focus on hypertension, and diabetes. Here we outline study design decisions and statistical considerations for the sampling of 4,400 BioMedioR participants.
The population for biomarker assessment was selected using a random sample study design balanced across race and sex to provide the optimal opportunity to describe association of biomarkers with the development of hypertension and diabetes. Descriptive characteristics of the BioMedioR sample and analytic plans are provided for this nested cohort study.
This nested biomarker study will examine pathways with the target to help explain racial differences in hypertension and diabetes incidence.
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Details
- Title
- Biomarkers as MEDiators of racial disparities in risk factors (BioMedioR): Rationale, study design, and statistical considerations
- Creators
- D. Leann Long - University of Alabama at BirminghamBoyi Guo - University of Alabama at BirminghamLeslie A. McClure - Drexel UniversityByron C. Jaeger - University of Alabama at BirminghamStephanie E. Tison - University of Alabama at BirminghamGeorge Howard - University of Alabama at BirminghamSuzanne E. Judd - University of Alabama at BirminghamVirginia J. Howard - University of Alabama at BirminghamTimothy B. Plante - University of VermontNeil A. Zakai - University of VermontInsu Koh - University of VermontKatharine L. Cheung - University of VermontMary Cushman - University of Vermont
- Publication Details
- Annals of epidemiology, v 66, pp 13-19
- Publisher
- Elsevier
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Epidemiology and Biostatistics
- Web of Science ID
- WOS:000912839600002
- Scopus ID
- 2-s2.0-85120870028
- Other Identifier
- 991019173622304721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Public, Environmental & Occupational Health