Journal article
Biomarkers for systemic lupus erythematosus
Translational research : the journal of laboratory and clinical medicine, v 159(4), pp 326-342
01 Apr 2012
PMID: 22424435
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
The urgent need for lupus biomarkers was demonstrated in September 2011 during a Workshop sponsored by the Food and Drug Administration: Potential Biomarkers Predictive of Disease Flare. After 2 days of discussion and more than 2 dozen presentations from thought leaders in both industry and academia, it became apparent that highly sought biomarkers to predict lupus flare have not yet been identified. Even short of the elusive biomarker of flare, few biomarkers for systemic lupus erythematosus (SLE) diagnosis, monitoring, and stratification have been validated and employed for making clinical decisions. This lack of reliable, specific biomarkers for SLE hampers proper clinical management of patients with SLE and impedes development of new lupus therapeutics. As such, the intensity of investigation to identify lupus biomarkers is climbing a steep trajectory, lending cautious optimism that a validated panel of biomarkers for lupus diagnosis, monitoring, stratification, and prediction of flare may soon be in hand.
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Details
- Title
- Biomarkers for systemic lupus erythematosus
- Creators
- Joseph M Ahearn - Allegheny-Singer Research InstituteChau-Ching LiuAmy H Kao - Allegheny-Singer Research InstituteSusan Manzi - Allegheny Health Network
- Publication Details
- Translational research : the journal of laboratory and clinical medicine, v 159(4), pp 326-342
- Publisher
- Elsevier
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Medicine (Graduate); General Internal Medicine
- Web of Science ID
- WOS:000301912700012
- Scopus ID
- 2-s2.0-84863337742
- Other Identifier
- 991021933899304721
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- Web of Science research areas
- Medical Laboratory Technology
- Medicine, Research & Experimental