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Journal article
Biomarkers of Sensitivity and Exposure in Washington State Pesticide Handlers
PARAOXONASES IN INFLAMMATION, INFECTION, AND TOXICOLOGY, v 660, pp 19-27
01 Jan 2010
PMCID: PMC3041670
PMID: 20221867
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Organophosphate (OP) and N-methyl-carbamate (CB) insecticides are widely used in agriculture in the US and abroad. These compounds which inhibit acetylcholinestersase (AChE) enzyme activity continue to be responsible for a high proportion of pesticide poisonings among US agricultural workers. It is possible that some individuals may be especially susceptible to health effects related to OP/CB exposure. The paraoxonase (PUN 1) enzyme metabolizes the highly toxic oxon forms of some OPs, and an individual's PON1 status may be an important determinant of his or her sensitivity to these chemicals. This chapter discusses methods used to characterize the PUN I status of individuals and reviews previous epidemiologic studies that have evaluated PON1-related sensitivity to OPs in relation to various health endpoints. It also describes an ongoing longitudinal study among OP-exposed agricultural pesticide handlers who are participating in a recently implemented cholinesterase monitoring program in Washington State. This study will evaluate handlers' PUN I status as a hypothesized determinant of butyrylcholinesterase (BuChE) inhibition. Such studies will be useful to determine how regulatory risk assessments might account for differences in PON1-related OP sensitivity when characterizing inter-individual variability in risk related to OP exposure. Recent work assessing newer and more sensitive biomarkers of OP exposure is also discussed briefly in this chapter.
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Details
- Title
- Biomarkers of Sensitivity and Exposure in Washington State Pesticide Handlers
- Creators
- Jonathan N. Hofmann - National Cancer InstituteMatthew C. Keifer - University of WashingtonHarvey Checkoway - University of WashingtonAnneclaire J. De Roos - University of WashingtonFederico M. Farin - University of WashingtonRichard A. Fenske - University of WashingtonRebecca J. Richter - University of WashingtonGerald van Belle - University of WashingtonClement E. Furlong - University of Washington
- Contributors
- S T Reddy (Editor)
- Publication Details
- PARAOXONASES IN INFLAMMATION, INFECTION, AND TOXICOLOGY, v 660, pp 19-27
- Series
- Advances in Experimental Medicine and Biology
- Publisher
- Springer Nature
- Number of pages
- 9
- Grant note
- P42ES004696 / NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Environmental Health Sciences (NIEHS) U50OH07544; T42OH008433 / CDC/NIOSH; United States Department of Health & Human Services; Centers for Disease Control & Prevention - USA; National Institute for Occupational Safety & Health (NIOSH) 5T42OH008433-09 / NIOSH; United States Department of Health & Human Services; Centers for Disease Control & Prevention - USA; National Institute for Occupational Safety & Health (NIOSH) P30ES07033; T32ES07262; P42ES04696; ES009883 / NIEHS; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Environmental Health Sciences (NIEHS) T42OH008433 / NATIONAL INSTITUTE FOR OCCUPATIONAL SAFETY AND HEALTH; United States Department of Health & Human Services; Centers for Disease Control & Prevention - USA; National Institute for Occupational Safety & Health (NIOSH)
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Environmental and Occupational Health
- Web of Science ID
- WOS:000276140000003
- Scopus ID
- 2-s2.0-79952102699
- Other Identifier
- 9781607613503; 1607613506; 991020099923104721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Medicine, Research & Experimental