Journal article
Biomaterials and Bioactive Factor Delivery Systems for the Control of Macrophage Activation in Regenerative Medicine
ACS biomaterials science & engineering, v 4(4), pp 1137-1148
01 Apr 2018
PMID: 33418652
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Macrophages play an important role in tissue repair, regeneration, and the ability of biomaterials to mediate these processes. Macrophages are highly plastic cells that exhibit altered behavior in response to changes in the micro environment. With the growing knowledge of the roles that different macrophage phenotypes play in specific pathologies and/or injuries, researchers are now focusing on designing biomaterials to actively control macrophage behavior and promote healing outcomes. In this review, we highlight a variety of biomaterial strategies for controlling macrophage phenotype in chronic wounds, tissue defects, and inflammatory conditions, although these strategies can be applied to many other applications. In particular, we highlight the different situations in which biomaterials should inhibit or promote Ml or M2 activation, or both, for therapeutic outcomes.
Metrics
Details
- Title
- Biomaterials and Bioactive Factor Delivery Systems for the Control of Macrophage Activation in Regenerative Medicine
- Creators
- Pamela L. Graney - Drexel UniversityEmily B. Lurier - Drexel UniversityKara L. Spiller - Drexel University
- Publication Details
- ACS biomaterials science & engineering, v 4(4), pp 1137-1148
- Publisher
- American Chemical Society; Washington, DC
- Number of pages
- 23
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- School of Biomedical Engineering, Science, and Health Systems
- Web of Science ID
- WOS:000429886800004
- Scopus ID
- 2-s2.0-85045213828
- Other Identifier
- 991019169602204721
UN Sustainable Development Goals (SDGs)
This publication has contributed to the advancement of the following goals:
InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Web of Science research areas
- Materials Science, Biomaterials