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Biomechanical properties of murine TMJ articular disc and condyle cartilage via AFM-nanoindentation
Journal article   Open access   Peer reviewed

Biomechanical properties of murine TMJ articular disc and condyle cartilage via AFM-nanoindentation

Prashant Chandrasekaran, Basak Doyran, Qing Li, Biao Han, Till E. Bechtold, Eiki Koyama, X. Lucas Lu and Lin Han
Journal of biomechanics, v 60
26 Jul 2017
DOI: https://doi.org/10.1016/j.jbiomech.2017.06.031
PMID: 28688538
Featured in Collection :   UN Sustainable Development Goals @ Drexel
url
https://europepmc.org/articles/pmc5582691View
Accepted (AM)Open Access (License Unspecified),  Open

Abstract

Fibrocartilage Heterogeneity Murine models Nanoindentation Temporomandibular joint
This study aims to quantify the biomechanical properties of murine temporomandibular joint (TMJ) articular disc and condyle cartilage using AFM-nanoindentation. For skeletally mature, 3-month old mice, the surface of condyle cartilage was found to be significantly stiffer (306±84kPa, mean±95% CI) than those of the superior (85±23kPa) and inferior (45±12kPa) sides of the articular disc. On the disc surface, significant heterogeneity was also detected across multiple anatomical sites, with the posterior end being the stiffest and central region being the softest. Using SEM, this study also found that the surfaces of disc are composed of anteroposteriorly oriented collagen fibers, which are sporadically covered by thinner random fibrils. Such fibrous nature results in both an F-D3/2 indentation response, which is a typical Hertzian response for soft continuum tissue under a spherical tip, and a linear F-D response, which is typical for fibrous tissues, further signifying the high degree of tissue heterogeneity. In comparison, the surface of condyle cartilage is dominated by thinner, randomly oriented collagen fibrils, leading to Hertzian-dominated indentation responses. As the first biomechanical study of murine TMJ, this work will provide a basis for future investigations of TMJ tissue development and osteoarthritis in various murine TMJ models.

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24 citations in Web of Science
24 citations in Scopus

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Collaboration types
Domestic collaboration
International collaboration
Web of Science research areas
Biophysics
Engineering, Biomedical
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