Journal article
Biomechanical properties of murine TMJ articular disc and condyle cartilage via AFM-nanoindentation
Journal of biomechanics, v 60
26 Jul 2017
PMID: 28688538
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
This study aims to quantify the biomechanical properties of murine temporomandibular joint (TMJ) articular disc and condyle cartilage using AFM-nanoindentation. For skeletally mature, 3-month old mice, the surface of condyle cartilage was found to be significantly stiffer (306±84kPa, mean±95% CI) than those of the superior (85±23kPa) and inferior (45±12kPa) sides of the articular disc. On the disc surface, significant heterogeneity was also detected across multiple anatomical sites, with the posterior end being the stiffest and central region being the softest. Using SEM, this study also found that the surfaces of disc are composed of anteroposteriorly oriented collagen fibers, which are sporadically covered by thinner random fibrils. Such fibrous nature results in both an F-D3/2 indentation response, which is a typical Hertzian response for soft continuum tissue under a spherical tip, and a linear F-D response, which is typical for fibrous tissues, further signifying the high degree of tissue heterogeneity. In comparison, the surface of condyle cartilage is dominated by thinner, randomly oriented collagen fibrils, leading to Hertzian-dominated indentation responses. As the first biomechanical study of murine TMJ, this work will provide a basis for future investigations of TMJ tissue development and osteoarthritis in various murine TMJ models.
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Details
- Title
- Biomechanical properties of murine TMJ articular disc and condyle cartilage via AFM-nanoindentation
- Creators
- Prashant Chandrasekaran - Drexel UniversityBasak Doyran - Drexel UniversityQing Li - Drexel UniversityBiao Han - School of Biomedical Engineering, Science, and Health Systems, Drexel University, Philadelphia, PA 19104, United StatesTill E. Bechtold - Children's Hospital of PhiladelphiaEiki Koyama - Children's Hospital of PhiladelphiaX. Lucas Lu - University of DelawareLin Han - Drexel University
- Publication Details
- Journal of biomechanics, v 60
- Publisher
- Elsevier
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- School of Biomedical Engineering, Science, and Health Systems
- Web of Science ID
- WOS:000408287300017
- Scopus ID
- 2-s2.0-85021837317
- Other Identifier
- 991019168980504721
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- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Biophysics
- Engineering, Biomedical