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Published, Version of Record (VoR)Open Access (License Unspecified), Open
Journal article
Biomimetic Approaches for Bone Tissue Engineering
Tissue engineering. Part B, Reviews, v 23(5), pp 480-493
01 Oct 2017
PMID: 27912680
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Although autologous bone grafts are considered a gold standard for the treatment of bone defects, they are limited by donor site morbidities and geometric requirements. We propose that tissue engineering technology can overcome such limitations by recreating fully viable and biological bone grafts. Specifically, we will discuss the use of bone scaffolds and autologous cells with bioreactor culture systems as a tissue engineering paradigm to grow bone
in vitro
. We will also discuss emergent vascularization strategies to promote graft survival
in vivo
, as well as the role of inflammation during bone repair. Finally, we will highlight some recent advances and discuss new solutions to bone repair inspired by endochondral ossification.
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Details
- Title
- Biomimetic Approaches for Bone Tissue Engineering
- Creators
- Johnathan Ng - Columbia UniversityKara Spiller - Drexel UniversityJonathan Bernhard - Columbia UniversityGordana Vunjak-Novakovic - Columbia University
- Publication Details
- Tissue engineering. Part B, Reviews, v 23(5), pp 480-493
- Publisher
- Mary Ann Liebert, Inc
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- School of Biomedical Engineering, Science, and Health Systems
- Web of Science ID
- WOS:000413101000006
- Scopus ID
- 2-s2.0-85028926011
- Other Identifier
- 991019168635904721
UN Sustainable Development Goals (SDGs)
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InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Biotechnology & Applied Microbiology
- Cell & Tissue Engineering
- Cell Biology
- Engineering, Biomedical
- Materials Science, Biomaterials