Journal article
Biomimetic Mineralization of Hierarchical Nanofiber Shish-Kebabs in a Concentrated Apatite-Forming Solution
ACS applied bio materials, v 4(1), pp 571-580
18 Jan 2021
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Recently, hierarchical polymer nanostructures called nanofiber shish-kebabs (NFSKs) have shown great potential in directing the distribution of minerals for biomineralization. In this work, we report controlled biomimetic mineralization in block copolymer-containing NFSKs. NFSKs were formed by crystallizing polycaprolactone-block-poly(acrylic acid) (PCL-b-PAA) kebabs on PCL fiber backbones. The block copolymer kebabs were periodically distributed on PCL nanofibers with a spacing of similar to 100-300 nm. Free ions could infiltrate into anionic PAA nanodomains and initiate the NFSK-templated biomimetic mineralization process. A concentrated calcium phosphate solution was used in the present study, which led to significantly accelerated mineralization kinetics compared with the previously studied simulated body fluid systems. Electron microscopy, Fourier-transform infrared spectroscopy, and wide-angle X-ray diffraction were used to characterize the structure and morphology of the mineralized NFSKs. A three-stage mineralization process was identified, and carbonated nonstoichiometric hydroxyapatite was observed after stage 2 with the mineral location templated within kebabs. This accelerated mineralization process yielded a periodic mineral distribution of a biomimetic calcium phosphate phase along the fibers, and the decrease in mineral formation time allows for more efficient biomineralization study and composite formation.
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Details
- Title
- Biomimetic Mineralization of Hierarchical Nanofiber Shish-Kebabs in a Concentrated Apatite-Forming Solution
- Creators
- Sarah E. Gleeson - Drexel UniversitySeyong Kim - Drexel UniversityQian Qian - Drexel UniversityTony Yu - Drexel UniversityMichele Marcolongo - Drexel UniversityChristopher Y. Li - Drexel University
- Publication Details
- ACS applied bio materials, v 4(1), pp 571-580
- Publisher
- American Chemical Society; Washington, DC
- Number of pages
- 10
- Grant note
- Department of Education Graduate Assistance in Areas of National Need; US Department of Education Drexel Dare grant DMR-1507760; CMMI 1762626 / National Science Foundation; National Science Foundation (NSF) 1646737 / National Science Foundation Graduate Research Fellowship; National Science Foundation (NSF)
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Materials Science and Engineering
- Web of Science ID
- WOS:000643599900038
- Scopus ID
- 2-s2.0-85099257757
- Other Identifier
- 991019169013004721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Materials Science, Biomaterials
- Nanoscience & Nanotechnology