Journal article
Biomimetic Proteoglycans Mimic Macromolecular Architecture and Water Uptake of Natural Proteoglycans
Biomacromolecules, v 18(6), pp 1713-1723
01 Jun 2017
PMID: 28398752
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Aging and degeneration of human tissue come with the loss of tissue water retention and associated changes in physical properties partially due to degradation and subsequent loss of proteoglycans. We demonstrated a novel method of fabrication of biomimetic proteoglycans, which mimic the three-dimensional bottlebrush architecture and physical behavior of natural proteoglycans responsible for tissue hydration and structural integrity. Biomimetic proteoglycans are synthesized by an end-on attachment of natural chondroitin sulfate bristles to a synthetic poly(acryloyl chloride) backbone. Atomic force microscopy imaging suggested three-dimensional core-bristle architecture, and hydrodynamic size of biomimetic proteoglycans was estimated at 61.3 +/- 12.3 nm using dynamic light scattering. Water uptake results indicated that biomimetic proteoglycans had a similar to 50% increased water uptake compared to native aggrecan and chondroitin sulfate alone. The biomimetic proteoglycans are cytocompatible in the physiological ranges of concentrations and could be potentially used to repair damaged or diseased tissue with depleted proteoglycan content.
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Details
- Title
- Biomimetic Proteoglycans Mimic Macromolecular Architecture and Water Uptake of Natural Proteoglycans
- Creators
- Katsiaryna Prudnikova - Drexel UniversityRobert W. Yucha - Drexel UniversityPavan Patel - Drexel UniversityAlicia S. Kriete - Drexel UniversityLin Han - Drexel Univ, Sch Biomed Engn Sci & Hlth Syst, 3141 Chestnut St, Philadelphia, PA 19104 USALynn S. Penn - Drexel UniversityMichele S. Marcolongo - Drexel University
- Publication Details
- Biomacromolecules, v 18(6), pp 1713-1723
- Publisher
- American Chemical Society; Washington, DC
- Number of pages
- 11
- Grant note
- R21AR066824 / NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Arthritis & Musculoskeletal & Skin Diseases (NIAMS) Wallace H. Coulter Foundation Drexel Areas of Research Excellence (DARE)
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- School of Biomedical Engineering, Science, and Health Systems; Materials Science and Engineering; Chemistry
- Web of Science ID
- WOS:000403387100005
- Scopus ID
- 2-s2.0-85020741737
- Other Identifier
- 991019169910004721
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InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Web of Science research areas
- Biochemistry & Molecular Biology
- Chemistry, Organic
- Polymer Science