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Published, Version of Record (VoR)Open Access via Drexel Libraries Read and Publish Program 2024CC BY V4.0, Open
Journal article
Biomimetic Proteoglycans Strengthen the Pericellular Matrix of Normal and Osteoarthritic Human Cartilage
ACS biomaterials science & engineering, v 10(9), pp 5617-5623
12 Aug 2024
Featured in Collection : Research Supported by Drexel Libraries' OA Programs
Abstract
In osteoarthritis (OA), degradation of cartilage pericellular matrix (PCM), the proteoglycan-rich immediate cell microniche, is a leading event of disease initiation. This study demonstrated that biomimetic proteoglycans (BPGs) can diffuse into human cartilage from both normal and osteoarthritic donors and are preferentially localized within the PCM. Applying immunofluorescence (IF)-guided AFM nanomechanical mapping, we show that this localization of BPGs increases the PCM micromodulus of both normal and OA specimens. These results illustrate the capability of BPGs to integrate with degenerative tissues and support the translational potential of BPGs for treating human OA and other diseases associated with proteoglycan degradation.
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Details
- Title
- Biomimetic Proteoglycans Strengthen the Pericellular Matrix of Normal and Osteoarthritic Human Cartilage
- Creators
- Lin Han (Corresponding Author) - Drexel University, School of Biomedical Engineering, Science, and Health SystemsMichele S Marcolongo (Corresponding Author) - Villanova UniversityElizabeth R Kahle - Drexel UniversityHooman Fallahi - Drexel UniversityAnnika R. Bergstrom - Villanova UniversityAnita Li - Villanova UniversityColette E. Trouillot - Drexel UniversityMary K Mulcahey - Drexel University, Orthopedic/Orthopaedic SurgeryX. Lucas Lu - University of Delaware
- Publication Details
- ACS biomaterials science & engineering, v 10(9), pp 5617-5623
- Publisher
- ACS Publications
- Number of pages
- 7
- Grant note
This work was financially supported by the National Science Foundation (NSF) grant CMMI-1826202 (to M.S.M. and L.H.), National Institutes of Health (NIH) grant R01AR080139 (to M.S.M.), R01AR074490 (to L.H.) and R01AR074472 (to X.L.L.), as well as NIH grant P30AR069619 to the Penn Center for Musculoskeletal Disorders. We thank the Singh Center for Nanotechnology at the University of Pennsylvania for the use of TIRF MFP-3D, which is part of the National Nanotechnology Coordinated Infrastructure Program supported by the NSF grant NNCI-1542153. All imaging was performed at Drexel University's Cell Imaging Center.
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- School of Biomedical Engineering, Science, and Health Systems; Orthopedic/Orthopaedic Surgery
- Web of Science ID
- WOS:001289869100001
- Scopus ID
- 2-s2.0-85201161760
- Other Identifier
- 991021897115204721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Materials Science, Biomaterials