Journal article
Biomimetic proteoglycans can molecularly engineer early osteoarthritic cartilage in vivo
Journal of orthopaedic research, v 37(2), pp 403-411
Feb 2019
PMID: 30480335
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
ABSTRACT
Biomimetic proteoglycans (BPGs) have the potential to treat osteoarthritis (OA) given that these molecules mimic the structure and properties of natural proteoglycans, which are significantly reduced in OA. We examined the effects of BPGs injected into the intra‐articular space in an in vivo OA rabbit knee model and evaluated the effect on histological response, joint friction, and BPG distribution and retention. Rabbits underwent ACL transection to create an arthritic state after 5 weeks. OA rabbits were treated with BPGs or Euflexxa® (hyaluronic acid) intra‐articular injections. Non‐OA rabbits were injected similarly with BPGs; contralateral joints served as controls. The progression of OA and response to injections were evaluated using Mankin and gross grading systems indicating that mild OA was achieved in operated joints. The coefficient of friction (COF) of the intact knee joints were measured using a custom pendulum friction apparatus, showing that OA joints and OA + Euflexxa® joints demonstrated increased COF than non‐operated controls, while BPG‐injected non‐OA and OA + BPGs were not significantly different from non‐OA controls. Injected fluorescently labeled BPGs demonstrated that BPGs diffused into cartilage with localization in the pericellular region. © 2018 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 37:403–411, 2019.
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Details
- Title
- Biomimetic proteoglycans can molecularly engineer early osteoarthritic cartilage in vivo
- Creators
- Evan R Phillips - Drexel UniversityKatsiaryna Prudnikova - Drexel UniversityTuan Bui - Drexel UniversityAdam J Taylor - Drexel UniversityDiego A Galindo - Philadelphia College of Osteopathic MedicineRichard B Huneke - Drexel UniversityJ. Steve Hou - Drexel UniversityMary K Mulcahey - Tulane University School of MedicineMichele S Marcolongo - Drexel University
- Publication Details
- Journal of orthopaedic research, v 37(2), pp 403-411
- Publisher
- Wiley
- Number of pages
- 9
- Grant note
- Clinical and Translational Research Institute at Drexel University Coulter Foundation
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Microbiology and Immunology; Materials Science and Engineering; Orthopedic/Orthopaedic Surgery
- Web of Science ID
- WOS:000460780800015
- Scopus ID
- 2-s2.0-85059507738
- Other Identifier
- 991014878204404721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Orthopedics