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Accepted (AM)Open Access (License Unspecified), Open
Journal article
Biopolymer encapsulated live influenza virus as a universal CD8+ T cell vaccine against influenza virus
Vaccine, v 29(2), pp 314-322
16 Dec 2010
PMCID: PMC3004745
PMID: 21034826
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Current influenza virus vaccines primarily elicit antibodies and can be rendered ineffective by antigenic drift and shift. Vaccines that elicit CD8+ T cell responses targeting less variable proteins may function as universal vaccines that have broad reactivity against different influenza virus strains. To generate such a universal vaccine, we encapsulated live influenza virus in a biopolymer and delivered it to mice subcutaneously. This vaccine was safe, induced potent CD8+ T cell immunity and protected mice against heterosubtypic lethal challenge. Safety of subcutaneous (SQ) vaccination was tested in Rag−/−γc−/− double knockout mice which we show cannot control intranasal infection. Biopolymer encapsulation of live influenza virus could be used to develop universal CD8+ T cell vaccines against heterosubtypic and pandemic strains.
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Details
- Title
- Biopolymer encapsulated live influenza virus as a universal CD8+ T cell vaccine against influenza virus
- Creators
- Alina C. Boesteanu - Drexel UniversityNadarajan S. Babu - Drexel UniversityMargaret Wheatley - Drexel UniversityElisabeth S. Papazoglou - Drexel UniversityPeter D. Katsikis - Drexel University
- Publication Details
- Vaccine, v 29(2), pp 314-322
- Publisher
- Elsevier
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- School of Biomedical Engineering, Science, and Health Systems
- Web of Science ID
- WOS:000287057300020
- Scopus ID
- 2-s2.0-78649719322
- Other Identifier
- 991019168874204721
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InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Web of Science research areas
- Immunology
- Medicine, Research & Experimental