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Biopolymer encapsulated live influenza virus as a universal CD8+ T cell vaccine against influenza virus
Journal article   Open access   Peer reviewed

Biopolymer encapsulated live influenza virus as a universal CD8+ T cell vaccine against influenza virus

Alina C. Boesteanu, Nadarajan S. Babu, Margaret Wheatley, Elisabeth S. Papazoglou and Peter D. Katsikis
Vaccine, v 29(2), pp 314-322
16 Dec 2010
DOI: https://doi.org/10.1016/j.vaccine.2010.10.036
PMID: 21034826
Featured in Collection :   UN Sustainable Development Goals @ Drexel
url
https://europepmc.org/articles/pmc3004745View
Accepted (AM) Open Open Access (License Unspecified)

Abstract

CD8+ T cells Influenza virus Vaccine
Current influenza virus vaccines primarily elicit antibodies and can be rendered ineffective by antigenic drift and shift. Vaccines that elicit CD8+ T cell responses targeting less variable proteins may function as universal vaccines that have broad reactivity against different influenza virus strains. To generate such a universal vaccine, we encapsulated live influenza virus in a biopolymer and delivered it to mice subcutaneously. This vaccine was safe, induced potent CD8+ T cell immunity and protected mice against heterosubtypic lethal challenge. Safety of subcutaneous (SQ) vaccination was tested in Rag−/−γc−/− double knockout mice which we show cannot control intranasal infection. Biopolymer encapsulation of live influenza virus could be used to develop universal CD8+ T cell vaccines against heterosubtypic and pandemic strains.

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9 citations in Web of Science
12 citations in Scopus

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Web of Science research areas
Immunology
Medicine, Research & Experimental
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