Journal article
Bioprinting cell-laden matrigel for radioprotection study of liver by pro-drug conversion in a dual-tissue microfluidic chip
Biofabrication, v 3(3), pp 034112-034112
Sep 2011
PMID: 21881168
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
The objective of this paper is to introduce a novel cell printing and microfluidic system to serve as a portable ground model for the study of drug conversion and radiation protection of living liver tissue analogs. The system is applied to study behavior in ground models of space stress, particularly radiation. A microfluidic environment is engineered by two cell types to prepare an improved higher fidelity in vitro micro-liver tissue analog. Cell-laden Matrigel printing and microfluidic chips were used to test radiation shielding to liver cells by the pro-drug amifostine. In this work, the sealed microfluidic chip regulates three variables of interest: radiation exposure, anti-radiation drug treatment and single- or dual-tissue culture environments. This application is intended to obtain a scientific understanding of the response of the multi-cellular biological system for long-term manned space exploration, disease models and biosensors.
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Details
- Title
- Bioprinting cell-laden matrigel for radioprotection study of liver by pro-drug conversion in a dual-tissue microfluidic chip
- Creators
- J E Snyder - Drexel UniversityQ Hamid - Drexel UniversityC Wang - Drexel UniversityR Chang - Drexel UniversityK Emami - National Aeronautics and Space AdministrationH Wu - National Aeronautics and Space AdministrationW Sun - Drexel University
- Publication Details
- Biofabrication, v 3(3), pp 034112-034112
- Publisher
- Institute of Physics (IOP)
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Marketing; Chemical and Biological Engineering; Mechanical Engineering and Mechanics
- Web of Science ID
- WOS:000294955200014
- Scopus ID
- 2-s2.0-82055196892
- Other Identifier
- 991019168123204721
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InCites Highlights
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- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Engineering, Biomedical
- Materials Science, Biomaterials