Journal article
Bioprinting ofin vitrotumor models for personalized cancer treatment: a review
Biofabrication, v 12(4)
01 Oct 2020
PMID: 32470967
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Studying biological characteristics of tumors and evaluating the treatment effects require appropriatein vitrotumor models. However, the occurrence, progression, and migration of tumors involve spatiotemporal changes, cell-microenvironment and cell-cell interactions, and signal transmission in cells, which makes the construction ofin vitrotumor models extremely challenging. In the past few years, advances in biomaterials and tissue engineering methods, especially development of the bioprinting technology, have paved the way for innovative platform technologies forin vitrocancer research. Bioprinting can accurately control the distribution of cells, active molecules, and biomaterials. Furthermore, this technology recapitulates the key characteristics of the tumor microenvironment and constructsin vitrotumor models with bionic structures and physiological systems. These models can be used as robust platforms to study tumor initiation, interaction with the microenvironment, angiogenesis, motility and invasion, as well as intra- and extravasation. Bioprinted tumor models can also be used for high-throughput drug screening and validation and provide the possibility for personalized cancer treatment research. This review describes the basic characteristics of the tumor and its microenvironment and focuses on the importance and relevance of bioprinting technology in the construction of tumor models. Research progress in the bioprinting of monocellular, multicellular, and personalized tumor models is discussed, and comprehensive application of bioprinting in preclinical drug screening and innovative therapy is reviewed. Finally, we offer our perspective on the shortcomings of the existing models and explore new technologies to outline the direction of future development and application prospects of next-generation tumor models.
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Details
- Title
- Bioprinting ofin vitrotumor models for personalized cancer treatment: a review
- Creators
- Shuangshuang Mao - Tsinghua UniversityYuan Pang - Tsinghua UniversityTiankun Liu - Tsinghua UniversityYongchun Shao - Tsinghua UniversityJianyu He - Tsinghua UniversityHuayu Yang - Peking Union Medical College HospitalYilei Mao - Peking Union Medical College HospitalWei Sun - Tsinghua University
- Publication Details
- Biofabrication, v 12(4)
- Publisher
- Iop Publishing Ltd
- Number of pages
- 16
- Grant note
- 51805294 / National Natural Science Foundation of China; National Natural Science Foundation of China (NSFC) B17026 / 111 Project; Ministry of Education, China - 111 Project 20191080843 / Tsinghua University-Peking Union Medical College Hospital Initiative Scientific Research Program 3184049 / Beijing Natural Science Foundation 2018YFA0703004 / National Key Research and Development Program of China 20197050024 / Tsinghua University Initiative Scientific Research Program XDA15014300 / Strategic Priority Program (SPP) on Space Science
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Mechanical Engineering and Mechanics
- Web of Science ID
- WOS:000551672500001
- Scopus ID
- 2-s2.0-85088049397
- Other Identifier
- 991019167440104721
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- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Engineering, Biomedical
- Materials Science, Biomaterials