Journal article
Bioresponsive Immunotherapeutic Materials
Advanced materials (Weinheim), pp e2209778-e2209778
20 Apr 2023
PMID: 36639983
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
The human immune system is an interaction network of biological processes, and its dysfunction is closely associated with a wide array of diseases, such as cancer, infectious diseases, tissue damage, and autoimmune diseases. Manipulation of the immune response network in a desired and controlled fashion has been regarded as a promising strategy for maximizing immunotherapeutic efficacy and minimizing side effects. Integration of "smart" bioresponsive materials with immunoactive agents including small molecules, biomacromolecules, and cells can achieve on-demand release of agents at targeted sites to reduce overdose-related toxicity and alleviate off-target effects. This review highlights the design principles of bioresponsive immunotherapeutic materials and discusses the critical roles of controlled release of immunoactive agents from bioresponsive materials in recruiting, housing, and manipulating immune cells for evoking desired immune responses. Challenges and future directions from the perspective of clinical translation are also discussed.
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Details
- Title
- Bioresponsive Immunotherapeutic Materials
- Creators
- Jinpeng Han - Zhejiang UniversityTao Sheng - Zhejiang UniversityYuqi Zhang - Zhejiang UniversityHao Cheng - Drexel University, Materials Science and EngineeringJianqing Gao - Zhejiang UniversityJicheng Yu - Zhejiang UniversityZhen Gu - Massachusetts Institute of Technology
- Publication Details
- Advanced materials (Weinheim), pp e2209778-e2209778
- Publisher
- Wiley
- Number of pages
- 28
- Grant note
- 2-SRA-2021-1064-M-B / JDRF; Juvenile Diabetes Research Foundation Zhejiang University 32271380; 52233013 / National Natural Science Foundation of China; National Natural Science Foundation of China (NSFC) 2021YFA0909900 / National Key R&D Program of China Drexel University
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Materials Science and Engineering
- Web of Science ID
- WOS:000972600600001
- Scopus ID
- 2-s2.0-85153476742
- Other Identifier
- 991021886804304721
UN Sustainable Development Goals (SDGs)
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InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Chemistry, Multidisciplinary
- Chemistry, Physical
- Materials Science, Multidisciplinary
- Nanoscience & Nanotechnology
- Physics, Applied
- Physics, Condensed Matter