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Journal article
Bipolar disorder and metabolic syndrome: An international perspective
Journal of affective disorders, v 126(3), pp 366-387
01 Nov 2010
PMID: 20541810
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
The ubiquity and hazards posed by abnormal body composition and metabolic parameters in the bipolar population are a priority research and clinical issue. Herein, we summarize and synthesize international studies describing the rate of US National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III [ATP III])- and International Diabetes Federation (IDF)-defined metabolic syndrome and its criterion components in individuals with bipolar disorder.
We conducted a PubMed search of all English-language articles published between January 2005 and July 2009 with the following search terms: metabolic syndrome and bipolar disorder, mania and manic-depression. Articles selected for review were based on adequacy of sample size, the use of standardized experimental procedures, validated assessment measures, and overall manuscript quality.
The rate of metabolic syndrome in individuals with bipolar disorder is increased relative to the general population. Disparate estimates are reported ranging from comparability to approximately twofold greater than the general population. The increased hazard for metabolic syndrome amongst bipolar individuals is now documented in twelve countries from Europe, Australia, Asia, North and South America. The co-occurrence of metabolic syndrome in the bipolar population is associated with a more complex illness presentation, less favourable response to treatment, and adverse course and outcome. The association between metabolic syndrome and bipolar disorder is mediated/moderated by both iatrogenic and non-iatrogenic factors.
The increased hazard for metabolic syndrome in bipolar populations is due to the clustering of traditional (and emerging) risk factors as well as iatrogenic and health systems factors. Extant data support recommendations for prioritizing, surveillance, prevention, diagnosis and management of metabolic syndrome as routine care of the bipolar patient.
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Details
- Title
- Bipolar disorder and metabolic syndrome: An international perspective
- Creators
- Roger S. McIntyre - University of TorontoMarlon Danilewitz - University Health NetworkSamantha S. Liauw - University Health NetworkDavid E. Kemp - Case Western Reserve UniversityHa T.T. Nguyen - University Health NetworkLinda S. Kahn - University at Buffalo, State University of New YorkAaron Kucyi - University Health NetworkJoanna K. Soczynska - University of TorontoHanna O. Woldeyohannes - University Health NetworkAngela Lachowski - University Health NetworkByungsu Kim - University of UlsanJay Nathanson - University of TorontoMohammad Alsuwaidan - University Health NetworkValerie H. Taylor - McMaster University
- Publication Details
- Journal of affective disorders, v 126(3), pp 366-387
- Publisher
- Elsevier
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Psychological and Brain Sciences (Psychology)
- Web of Science ID
- WOS:000283901300004
- Scopus ID
- 2-s2.0-77957338107
- Other Identifier
- 991021448171504721
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InCites Highlights
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- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Clinical Neurology
- Psychiatry