Logo image
Back
Bisphenol A and phthalates in utero and in childhood: association with child BMI z-score and adiposity
Journal article   Open access   Peer reviewed

Bisphenol A and phthalates in utero and in childhood: association with child BMI z-score and adiposity

Tiffany C. Yang, Karen E. Peterson, John D. Meeker, Brisa N. Sanchez, Zhenzhen Zhang, Alejandra Cantoral, Maritsa Solano and Martha M. Tellez-Rojo
Environmental research, v 156, pp 326-333
01 Jul 2017
DOI: https://doi.org/10.1016/j.envres.2017.03.038
PMID: 28390300
Featured in Collection :   UN Sustainable Development Goals @ Drexel
url
https://europepmc.org/articles/pmc5482500View
Accepted (AM)Open Access (License Unspecified),  Open

Abstract

Environmental Sciences Environmental Sciences & Ecology Life Sciences & Biomedicine Public, Environmental & Occupational Health Science & Technology
Objective: To assess the relationship between in utero and concurrent child urinary exposures to bisphenol A (BPA) and phthalates with BMI z-score, waist circumference, and sum of triceps and subscapular skinfold thickness in Mexican children. Methods: Among participants (N = 249) from the Early Life Exposure in Mexico to ENvironmental Toxicants study, we evaluated associations between maternal third trimester and concurrent urinary BPA and individual and summed phthalates metabolites (Sigma Di(2-ethylhexyl phthalate), Thigh molecular weight, Zlow molecular weight) with measures of weight status and adiposity in children aged 8-14 years. Linear regressions with specific-gravity corrected and natural log-transformed urinary concentrations were estimated, adjusting for covariates. Effect modification by sex was explored. Results: Prenatal urinary exposure to monobenzyl phthalate (MBzP) was inversely associated with child's BMI z-score (beta = -0.21, 95%CI: -0.41, -0.02) and child urinary exposure to mono(2-ethylhexyl)phthalate (MEHP) was inversely associated with waist circumference (beta = -1.85, 95%CI: -3.36, -0.35) and sum of skinfold thicknesses (beta= -2.08, 95%CI: -3.80, -0.37) after adjusting for confounders. In the childhood exposure period, sex modified the relationships with BPA, MEHP, MBzP, monoethyl phthalate (MEP), mono(2-ethyl-5hydroxyhexyl) phthalate (MEHHP), mono(2-ethyl-5-oxohexyl) phthalate (MEOHP), and mono(2-ethyl-5-carboxypentyl) phthalate (MECPP). In girls, increased BPA exposure was positively associated with sum of skinfold thickness (beta = 3.47, 95%CI: 0.05, 6.40) while increased MEHP was inversely associated with sum of skinfold thicknesses in boys (beta = -2.95, 95%CI: -5.08, -0.82); these results remained in sensitivity analyses after excluding children who had initiated pubertal development (Tanner stage > 1 for pubic hair). We did not observe relationships between summed phthalates metabolites at any exposure period with outcome measures. Conclusion: Our results identified associations between urinary BPA and phthalates metabolites with measures of weight status and adiposity that differed by timing of exposure, sex, and pubertal status. Additional studies are needed to explore how associations may differ between those who are pre- and post-pubertal.

Metrics

15 Record Views
78 citations in Web of Science
78 citations in Scopus

Details

UN Sustainable Development Goals (SDGs)

This publication has contributed to the advancement of the following goals:

#3 Good Health and Well-Being

InCites Highlights

Data related to this publication, from InCites Benchmarking & Analytics tool:

Collaboration types
Domestic collaboration
International collaboration
Web of Science research areas
Environmental Sciences
Public, Environmental & Occupational Health
Logo image