Journal article
Black rice anthocyanidins prevent retinal photochemical damage via involvement of the AP-1/NF-κB/Caspase-1 pathway in Sprague-Dawley Rats
Journal of veterinary science (Suwŏn-si, Korea), v 14(3), pp 345-353
Sep 2013
PMID: 23820171
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
The effects of black rice anthocyanidins (BRACs) on retinal damage induced by photochemical stress are not well known. In the present study, Sprague-Dawley rats were fed AIN-93M for 1 week, after which 80 rats were randomly divided into two groups and treated with (n = 40) or without BRACs (n = 40) for 15 days, respectively. After treatment, both groups were exposed to fluorescent light (3,000 ± 200 lux; 25℃), and the protective effect of dietary BRACs were evaluated afterwards. Our results showed that dietary BRACs effectively prevented retinal photochemical damage and inhibited the retinal cells apoptosis induced by fluorescent light (
p
< 0.05). Moreover, dietary BRACs inhibited expression of AP-1 (c-fos/c-jun subunits), up-regulated NF-κB (p65) expression and phosphorylation of IκB-α, and decreased Caspase-1 expression (
p
< 0.05). These results suggest that BRACs improve retinal damage produced by photochemical stress in rats
via
AP-1/NF-κB/Caspase-1 apoptotic mechanisms.
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Details
- Title
- Black rice anthocyanidins prevent retinal photochemical damage via involvement of the AP-1/NF-κB/Caspase-1 pathway in Sprague-Dawley Rats
- Creators
- Hao Jia - Department of Public Health, Chengdu Medical College, Chengdu City, 610050, ChinaWei Chen - Department of Public Health, Chengdu Medical College, Chengdu City, 610050, ChinaXiaoping Yu - Department of Public Health, Chengdu Medical College, Chengdu City, 610050, ChinaXiuhua Wu - Department of Public Health, Chengdu Medical College, Chengdu City, 610050, ChinaShuai Li - Department of Public Health, Chengdu Medical College, Chengdu City, 610050, ChinaHong Liu - Department of Public Health, Chengdu Medical College, Chengdu City, 610050, ChinaJiru Liao - Department of Public Health, Chengdu Medical College, Chengdu City, 610050, ChinaWeihua Liu - Department of Public Health, Chengdu Medical College, Chengdu City, 610050, ChinaMantian Mi - Department of Nutrition and Food Hygiene, School of Preventive Medicine, The Third Military Medical University, Chongqing City, 400038, ChinaLongjian Liu - Department of Epidemiology and Bio-statistics, School of Public Health, Drexel University, Philadelphia, PA 19102, USADaomei Cheng - Department of Public Health, Chengdu Medical College, Chengdu City, 610050, China
- Publication Details
- Journal of veterinary science (Suwŏn-si, Korea), v 14(3), pp 345-353
- Publisher
- The Korean Society of Veterinary Science
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Epidemiology and Biostatistics
- Web of Science ID
- WOS:000325042800015
- Scopus ID
- 2-s2.0-84885339749
- Other Identifier
- 991014878627104721
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- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Veterinary Sciences