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Journal article
Blastic plasmacytoid dendritic cell neoplasm with absolute monocytosis at presentation
Pathology and laboratory medicine international, v 7(default), pp 7-10
01 Jan 2015
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Blastic plasmacytoid dendritic cell neoplasm is an uncommon malignancy derived from precursors of plasmacytoid dendritic cells. Nearly all patients present initially with cutaneous manifestations, with many having extracutaneous disease additionally. While response to chemotherapy initially is effective, relapse occurs in most, with a leukemic phase ultimately developing. The prognosis is dismal. While most of the clinical and pathologic features are well described, the association and possible prognostic significance between peripheral blood absolute monocytosis (>1.0 K/mu L) and blastic plasmacytoid dendritic cell neoplasm have not been reported. We report a case of a 68-year-old man who presented with a rash for 4-5 months. On physical examination, there were multiple, dull-pink, indurated plaques on the trunk and extremities. Complete blood count revealed thrombocytopenia, absolute monocytosis of 1.7 K/mu L, and a negative flow cytometry study. Biopsy of an abdominal lesion revealed typical features of blastic plasmacytoid dendritic cell neoplasm. Patients having both hematologic and nonhematologic malignancies have an increased incidence of absolute monocytosis. Recent studies examining Hodgkin and non-Hodgkin lymphoma patients have suggested that this is a negative prognostic factor. The association between blastic plasmacytoid dendritic cell neoplasm and absolute monocytosis has not been described and may, in fact, have prognostic value.
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Details
- Title
- Blastic plasmacytoid dendritic cell neoplasm with absolute monocytosis at presentation
- Creators
- Joseph M. Jaworski - Drexel Univ, Hahnemann Univ Hosp, Dept Pathol, Mail Stop 435,245 N 15th St, Philadelphia, PA 19102 USAVanlila K. Swami - Drexel UniversityRebecca C. Heintzelman - Drexel UniversityCarrie A. Cusack - Drexel Univ, Hahnemann Univ Hosp, Coll Med, Dept Dermatol, Philadelphia, PA 19102 USAChristina L. Chung - Drexel Univ, Hahnemann Univ Hosp, Coll Med, Dept Dermatol, Philadelphia, PA 19102 USAJeremy Peck - Drexel Univ, Hahnemann Univ Hosp, Coll Med, Dept Dermatol, Philadelphia, PA 19102 USAMatthew Fanelli - Drexel Univ, Hahnemann Univ Hosp, Coll Med, Dept Dermatol, Philadelphia, PA 19102 USAMicheal Styler - Drexel Univ, Hahnemann Univ Hosp, Coll Med, Dept Hematol, Philadelphia, PA 19104 USASanaa Rizk - Drexel Univ, Hahnemann Univ Hosp, Coll Med, Dept Hematol, Philadelphia, PA 19104 USAJ. Steve Hou - Drexel Univ, Hahnemann Univ Hosp, Dept Pathol, Mail Stop 435,245 N 15th St, Philadelphia, PA 19102 USA
- Publication Details
- Pathology and laboratory medicine international, v 7(default), pp 7-10
- Publisher
- Dove Medical Press Ltd
- Number of pages
- 4
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- [Retired Faculty]; Pathology (and Laboratory Medicine)
- Web of Science ID
- WOS:000215773300002
- Other Identifier
- 991019167959604721
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- Pathology