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Bleeding Complications in Neonates Receiving Extracorporeal Membrane Oxygenation and Controlled Hypothermia
Journal article   Peer reviewed

Bleeding Complications in Neonates Receiving Extracorporeal Membrane Oxygenation and Controlled Hypothermia

Swosti Joshi, Vilmaris Quinones Cardona, Erica Poletto and Ogechukwu Menkiti
American journal of perinatology
17 May 2022
DOI: https://doi.org/10.1055/a-1786-8688
PMID: 35240700
Featured in Collection :   UN Sustainable Development Goals @ Drexel

Abstract

Original Article
Abstract Objective  Safety and efficacy data on controlled hypothermia (CH) for neonates with moderate to severe hypoxic ischemic encephalopathy has been extrapolated to a subgroup of these patients who also require extracorporeal membrane oxygenation for refractory persistent pulmonary hypertension of the newborn (PPHN). However, safety data on the concomitant use of CH and extracorporeal membrane oxygenation (ECMO) are lacking. Methods  This is a single-center retrospective study of neonates ≥35 weeks' gestation with refractory PPHN who required ECMO between January 2010 and December 2020. Study groups were divided into those receiving CH/ECMO versus ECMO only. Baseline characteristics, short-term outcomes, and brain magnetic resonance imaging (MRI) data were compared. Results  A total of 36 neonates who received ECMO for refractory PPHN were included. Of these, 44.4% ( n  = 16) received CH/ECMO and 55.6% ( n  = 20) received ECMO only. Bleeding complications were more common in CH/ECMO group 50% ( n  = 8) versus ECMO only 15% ( n  = 3, p  = 0.023). T1 brain MRI severity scores were higher in CH/ECMO group versus ECMO only group, however, there were no statistical difference in T2 and diffusion-weighted image scores. Functional status and survival to discharge were comparable between groups. Conclusion  In our cohort, neonates who received CH/ECMO had higher bleeding complications than ECMO only group with comparable functional status and survival at discharge. Key Points Safety data on the concomitant use of CH and ECMO are lacking in neonates. In our cohort, neonates who received CH/ECMO had higher bleeding complications than ECMO only group. Functional status and survival to discharge were no differences between the two groups.

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2 citations in Scopus

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#3 Good Health and Well-Being

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Web of Science research areas
Obstetrics & Gynecology
Pediatrics
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