Journal article
Block copolymer crystalsomes with an ultrathin shell to extend blood circulation time
Nature communications, v 9(1), pp 3005-10
01 Aug 2018
PMID: 30068976
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
In water, amphiphilic block copolymers (BCPs) can self-assemble into various micelle structures depicting curved liquid/liquid interface. Crystallization, which is incommensurate with this curved space, often leads to defect accumulation and renders the structures leaky, undermining their potential biomedical applications. Herein we report using an emulsion-solution crystallization method to control the crystallization of an amphiphilic BCP, poly (L-lactide acid)-b-poly (ethylene glycol) (PLLA-b-PEG), at curved liquid/liquid interface. The resultant BCP crystalsomes (BCCs) structurally mimic the classical polymersomes and liposomes yet mechanically are more robust thanks to the single crystal-like crystalline PLLA shell. In blood circulation and biodistribution experiments, fluorophore-loaded BCCs show a 24 h circulation half-life and a 8% particle retention in the blood even at 96 h post injection. We further demonstrate that this good performance can be attributed to controlled polymer crystallization and the unique BCC nanostructure.
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Details
- Title
- Block copolymer crystalsomes with an ultrathin shell to extend blood circulation time
- Creators
- Hao Qi - Department of Materials Science and Engineering, Drexel University, Philadelphia, PA, 19104, USAHao Zhou - Department of Materials Science and Engineering, Drexel University, Philadelphia, PA, 19104, USAQiyun Tang - Institut für Theoretische Physik, Universität Göttingen, Friedrich-Hund-Platz 1, 37077, Göttingen, GermanyJee Young Lee - Department of Materials Science and Engineering, University of Delaware, Newark, DE, 19716, USAZhiyuan Fan - Department of Materials Science and Engineering, Drexel University, Philadelphia, PA, 19104, USASeyong Kim - Department of Materials Science and Engineering, Drexel University, Philadelphia, PA, 19104, USAMark C Staub - Department of Materials Science and Engineering, Drexel University, Philadelphia, PA, 19104, USATian Zhou - Department of Materials Science and Engineering, Drexel University, Philadelphia, PA, 19104, USAShan Mei - Department of Materials Science and Engineering, Drexel University, Philadelphia, PA, 19104, USALin Han - School of Biomedical Engineering, Science & Health Systems, Drexel University, Philadelphia, PA, 19104, USADarrin J Pochan - Department of Materials Science and Engineering, University of Delaware, Newark, DE, 19716, USAHao Cheng - Department of Materials Science and Engineering, Drexel University, Philadelphia, PA, 19104, USA. hcheng@drexel.eduWenbing Hu - Department of Polymer Science and Engineering, State Key Lab of Coordination Chemistry, School of Chemistry and Chemical Engineering, Nanjing University, 210023, Nanjing, ChinaChristopher Y Li - Department of Materials Science and Engineering, Drexel University, Philadelphia, PA, 19104, USA. chrisli@drexel.edu
- Publication Details
- Nature communications, v 9(1), pp 3005-10
- Publisher
- Springer Nature; England
- Grant note
- DMR 1709136 / National Science Foundation (NSF) DMR-1308958 / National Science Foundation (NSF) R21 AI133372 / NIAID NIH HHS
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- School of Biomedical Engineering, Science, and Health Systems; Materials Science and Engineering
- Web of Science ID
- WOS:000440413500005
- Scopus ID
- 2-s2.0-85050970884
- Other Identifier
- 991014877709704721
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- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Chemistry, Multidisciplinary