Journal article
Body Fluid Volumes in the Spontaneously Hypertensive Rat
Clinical science (1979), v 61(6), pp 685-691
01 Dec 1981
PMID: 7297034
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Abstract
1. Plasma volume, packed cell volume (PCV), blood volume, extracellular fluid volume (ECFV) and Evans blue disappearance rate were measured in conscious spontaneously hypertensive rats and in weight-matched Wistar normotensive rats.
2. Over the weight range studied (250-350 g), plasma and blood volumes were significantly lower in the spontaneously hypertensive rat. Extracellular fluid volumes were similar in the two groups. PCV arid Evans blue disappearance rates were significantly higher in the spontaneously hypertensive rat.
3. Negative correlations were obtained between plasma volume and mean arterial pressure and between the plasma/interstitial fluid volume ratio and mean arterial pressure.
4. the normal extracellular fluid volume and the lack of correlation with mean arterial pressure excludes volume expansion as a pressor mechanism during the established phase of hypertension in the spontaneously hypertensive rat.
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Details
- Title
- Body Fluid Volumes in the Spontaneously Hypertensive Rat
- Creators
- M. Bianchi - Hahnemann University HospitalG. Bellini - Hahnemann University HospitalH. Hessan - Hahnemann University HospitalK. E. Kim - Hahnemann University HospitalC. Swartz - Hahnemann University HospitalM. Fernandes - Hahnemann University Hospital
- Publication Details
- Clinical science (1979), v 61(6), pp 685-691
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Surgery
- Web of Science ID
- WOS:A1981MN70200005
- Scopus ID
- 2-s2.0-0019859422
- Other Identifier
- 991019184045304721
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- Medicine, Research & Experimental