Logo image
Back
Body Mass Index and the Association With Vaso-occlusive Crises in Pediatric Sickle Cell Disease
Journal article   Peer reviewed

Body Mass Index and the Association With Vaso-occlusive Crises in Pediatric Sickle Cell Disease

Andrea Zivot, Nataly Apollonsky, Edward Gracely and Deepti Raybagkar
Journal of pediatric hematology/oncology, v 39(4)
May 2017
DOI: https://doi.org/10.1097/MPH.0000000000000787
PMID: 28221266
Featured in Collection :   UN Sustainable Development Goals @ Drexel

Abstract

Adolescent Analgesics, Opioid - therapeutic use Anemia, Sickle Cell - complications Arterial Occlusive Diseases - etiology Arterial Occlusive Diseases - pathology Arterial Occlusive Diseases - physiopathology Body Mass Index Child Child, Preschool Hospitalization Humans Infant Infant, Newborn Obesity - etiology Pain Retrospective Studies Young Adult
Children with sickle cell disease (SCD) historically have been underweight and have poor overall growth. Recent studies have demonstrated a trend toward obesity in pediatric SCD populations. Through retrospective chart review of patients with SCD followed at our center, we collected patient's data, including body mass index (BMI), weight percentiles, sickle cell genotype, baseline hemoglobin, medical and psychiatric comorbidities, 25-hydroxy vitamin D level, treatment with hydroxyurea, and chronic transfusions. We identified hospitalizations to St. Christopher's Hospital for vaso-occlusive crisis (VOC) and duration of hospitalization and intravenous opioid use were recorded. Student t test, Mann-Whitney U test, and analysis of variance were used to examine associations between variables and frequency and duration of hospitalizations for VOC. Among 328 patients with SCD, overweight and obese children constituted 19% of hospitalized and nonhospitalized patients. BMI status did not influence frequency (P=0.90) or duration of hospitalization (P=0.65) for VOC. Obesity was more associated with HbSC than HbSS (P=0.025) genotype. Our study did not demonstrate an association between extremes of BMI of patients and hospitalization for VOC. Considering current trend toward obesity, further prospective and interventional research are required to define the effects of extremes of BMI on pain crises in SCD.

Metrics

17 Record Views
10 citations in Web of Science
10 citations in Scopus

Details

UN Sustainable Development Goals (SDGs)

This publication has contributed to the advancement of the following goals:

#3 Good Health and Well-Being

InCites Highlights

Data related to this publication, from InCites Benchmarking & Analytics tool:

Web of Science research areas
Hematology
Oncology
Pediatrics
Logo image