Journal article
Body fat distribution in perinatally HIV-infected and HIV-exposed but uninfected children in the era of highly active antiretroviral therapy: outcomes from the Pediatric HIV/AIDS Cohort Study
The American journal of clinical nutrition, v 94(6), pp 1485-1495
01 Dec 2011
PMID: 22049166
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Background: Associations between abnormal body fat distribution and clinical variables are poorly understood in pediatric HIV disease.
Objective: Our objective was to compare total body fat and its distribution in perinatally HIV-infected and HIV-exposed but un-infected (HEU) children and to evaluate associations with clinical variables.
Design: In a cross-sectional analysis, children aged 7-16 y in the Pediatric HIV/AIDS Cohort Study underwent regionalized measurements of body fat via anthropometric methods and dual-energy X-ray absorptiometry. Multiple linear regression was used to evaluate body fat by HIV, with adjustment for age, Tanner stage, race, sex, and correlates of body fat in HIV-infected children. Percentage total body fat was compared with NHANES data.
Results: Males accounted for 47% of the 369 HIV-infected and 51% of the 176 HEU children. Compared with HEU children, HIV-infected children were older, were more frequently non-Hispanic black, more frequently had Tanner stage >= 3, and had lower mean height (-0.32 compared with 0.29), weight (0.13 compared with 0.70), and BMI (0.33 compared with 0.63) z scores. On average, HIV-infected children had a 5% lower percentage total body fat (TotF), a 2.8% lower percentage extremity fat (EF), a 1.4% higher percentage trunk fat (TF), and a 10% higher trunk-to- extremity fat ratio (TEFR) than did the HEU children and a lower TotF compared with NHANES data. Stavudine use was associated with lower EF and higher TF and TEFR. Non-nucleotide reverse transcriptase inhibitor use was associated with higher TotF and EF and lower TEFR.
Conclusion: Although BMI and total body fat were significantly lower in the HIV-infected children than in the HEU children, body fat distribution in the HIV-infected children followed a pattern associated with cardiovascular disease risk and possibly related to specific antiretroviral drugs. Am J Clin Nutr 2011; 94: 1485-95.
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Details
- Title
- Body fat distribution in perinatally HIV-infected and HIV-exposed but uninfected children in the era of highly active antiretroviral therapy: outcomes from the Pediatric HIV/AIDS Cohort Study
- Creators
- Denise L. Jacobson - Harvard University ,Kunjal Patel - Harvard University ,George K. Siberry - National Institutes of HealthRussell B. Van Dyke - Tulane UniversityLinda A. DiMeglio - Indiana University BloomingtonMitchell E. Geffner - University of Southern CaliforniaJanet S. Chen - Drexel UniversityElizabeth J. McFarland - University of DenverWilliam Borkowsky - New York UniversityMargarita Silio - Tulane UniversityRoger A. Fielding - Tufts UniversitySuzanne Siminski - Frontier Science & Technology Research FoundationTracie L. Miller - University of Miami*Pediat HIV AIDS Cohort Study
- Publication Details
- The American journal of clinical nutrition, v 94(6), pp 1485-1495
- Publisher
- Oxford Univ Press
- Number of pages
- 11
- Grant note
- National Institute on Alcohol Abuse and Alcoholism; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute on Alcohol Abuse & Alcoholism (NIAAA) U01HD052102 / EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD) National Institute of Mental Health; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Mental Health (NIMH) National Heart, Lung, and Blood Institute; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Heart Lung & Blood Institute (NHLBI) HD052102 / Harvard University School of Public Health HD052104 / Tulane University School of Medicine National Institute of Neurological Disorders and Stroke; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Neurological Disorders & Stroke (NINDS) National Institute of Deafness and Other Communication Disorders; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute on Deafness & Other Communication Disorders (NIDCD) Eunice Kennedy Shriver National Institute of Child Health and Human Development; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD) Westat, Inc National Institute of Allergy and Infectious Diseases; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Allergy & Infectious Diseases (NIAID) National Institute on Drug Abuse; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute on Drug Abuse (NIDA); European Commission Frontier Science and Technology Research Foundation
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Pediatrics
- Web of Science ID
- WOS:000297368700016
- Scopus ID
- 2-s2.0-82355163508
- Other Identifier
- 991019168561704721
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- Collaboration types
- Industry collaboration
- Domestic collaboration
- Web of Science research areas
- Nutrition & Dietetics