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Body mass index and CD4+ T-lymphocyte recovery in HIV-infected men with viral suppression on antiretroviral therapy
Journal article   Open access

Body mass index and CD4+ T-lymphocyte recovery in HIV-infected men with viral suppression on antiretroviral therapy

Brandon Palermo, Ronald J Bosch, Kara Bennett and Jeffrey M Jacobson
HIV clinical trials, v 12(4)
Jul 2011
PMID: 22044858
url
https://www.tandfonline.com/doi/pdf/10.1310/hct1204-222?needAccess=trueView
Published, Version of Record (VoR) Open
url
https://doi.org/10.1310/hct1204-222View
Published, Version of Record (VoR) Open

Abstract

Adult Anti-Retroviral Agents - therapeutic use Body Mass Index CD4 Lymphocyte Count HIV Infections - drug therapy HIV Infections - immunology HIV Infections - virology Humans Leptin - blood Male Middle Aged
To better characterize the relationship between body mass index (BMI) and CD4+ T-lymphocyte recovery in HIV disease. We analyzed the association between baseline BMI and CD4+ T-lymphocyte increases, as well as the association between BMI and immune activation (CD38 and HLA-DR co-expression on CD4+ and CD8+ T-lymphocytes), in male HIV-infected patients who achieved viral suppression on antiretroviral therapy (ART). Baseline BMI predicted change in CD4+ T-lymphocyte count at weeks 96 ( P = .03, n = 461) and 144 ( P = .005, n = 357) but not at week 48 ( P = .38, n = 558). Relative to men with a normal BMI, overweight and obese men had increases at week 144 that were 35 and 113 cells/ mm3 higher, respectively, while underweight men had CD4+ T-lymphocyte increases that were 94 cells/mm3 lower. No significant correlations between baseline BMI and cellular immune activation were seen. BMI predicts CD4+ T-lymphocyte gains in men started on ART.

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32 citations in Scopus

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Collaboration types
Domestic collaboration
Web of Science research areas
Infectious Diseases
Pharmacology & Pharmacy
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