Journal article
Body weight regulation by selective MC4 receptor agonists and antagonists
Annals of the New York Academy of Sciences, v 994(1), pp 103-110
Jun 2003
PMID: 12851304
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
There has been great interest in melanocortin (MC) receptors as targets for the design of novel therapeutics to treat disorders of body weight, such as obesity and cachexia. Both genetic and pharmacological evidence points toward central MC4 receptors as the principal target. Using highly selective peptide tools for the MC4 receptor, which have become available recently, we have provided pharmacological confirmation that central MC4 receptors are the prime mediators of the anorexic and orexigenic effects reported for melanocortin agonists and antagonists, respectively. The current progress with receptor-selective small molecule agonist and antagonist drugs should enable the therapeutic potential of MC4 receptor activation and inhibition to be assessed in the clinic in the near future.
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Details
- Title
- Body weight regulation by selective MC4 receptor agonists and antagonists
- Creators
- Alam C Foster - Neurocrine BiosciencesMargaret Joppa - Neurocrine BiosciencesStacy Markison - Neurocrine BiosciencesKathy R Gogas - Neurocrine BiosciencesBeth A Fleck - Neurocrine BiosciencesBrian J Murphy - Neurocrine BiosciencesMeira Wolff - Neurocrine BiosciencesMary J Cismowski - Neurocrine BiosciencesNicholas Ling - Neurocrine BiosciencesVal S Goodfellow - Neurocrine BiosciencesChen Chen - Neurocrine BiosciencesJohn Saunders - Neurocrine BiosciencesPaul J Conlon - Neurocrine Biosciences
- Publication Details
- Annals of the New York Academy of Sciences, v 994(1), pp 103-110
- Publisher
- Wiley
- Grant note
- 1 R43 DK57969-01 / NIDDK NIH HHS 1 R43 CA93190-0 / NCI NIH HHS
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Pharmacology and Physiology
- Web of Science ID
- WOS:000184303800013
- Scopus ID
- 2-s2.0-0037713324
- Other Identifier
- 991021903309704721
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InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Web of Science research areas
- Biochemistry & Molecular Biology
- Endocrinology & Metabolism
- Neurosciences