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Bone Accrual Trajectories in Children and Adolescents with Perinatal HIV Infection
Journal article   Open access   Peer reviewed

Bone Accrual Trajectories in Children and Adolescents with Perinatal HIV Infection

Linda Anne DiMeglio, Wendy Yu, Heidi J Kalkwarf, Sean Brummel, Janet S Chen, Mitchell E Geffner, Elizabeth J McFarland, Ayesha Mirza, Kunjal Patel, Stephanie Shiau, …
The journal of clinical endocrinology and metabolism
23 Sep 2024
url
https://doi.org/10.1210/clinem/dgae631View
Published, Version of Record (VoR) Restricted

Abstract

HIV bone children density growth trajectories
Abstract Context Low bone mineral density (BMD) has been reported in children and adolescents living with perinatally-acquired HIV (PHIV). Little is known about their bone accrual through puberty compared to an uninfected healthy cohort. Objective To compare bone accrual in PHIV and healthy children. Design PHIV children aged 7-16 years had dual energy X-ray absorptiometry (DXA) at entry, 2 years, and then at least 2 years later. Bone accrual was compared to healthy children from the Bone Mineral Density in Childhood Study (BMDCS). Setting United States academic clinical research centers. Patients 172 PHIV; 1321 BMDCS. Analysis We calculated height-adjusted whole-body and spine BMD and bone mineral content (BMC) Z-scores in PHIV using BMDCS reference curves. We fit piecewise weighted linear mixed effects models with change points at 11 and 15 years, adjusted for age, sex, race, height Z-score, and Tanner stage, to compare BMD and BMC Z-scores across actual age by cohort. Main Outcome Measure: BMD/BMC Z-scores. Results Height-adjusted whole-body BMD and BMC Z-scores in PHIV were lower across age compared to BMDCS children. Spine BMD Z-score across age was higher in PHIV after height adjustment. Whole-body and spine bone area tended to be lower in PHIV. PHIV had slower accrual in whole-body and spine bone area before 14 years. After 15 years, bone area accruals were similar, as were height-adjusted spine BMC Z-scores, across age. Conclusions PHIV had persistent deficits in all measures except height-adjusted spine BMD and BMC Z-scores. Data are needed on PHIV followed to adulthood.

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Collaboration types
Domestic collaboration
Web of Science research areas
Endocrinology & Metabolism
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