Journal article
Bone Loss from High Repetitive High Force Loading is Prevented by Ibuprofen Treatment
Journal of musculoskeletal & neuronal interactions, v 14(1)
01 Mar 2014
PMID: 24583543
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
We examined roles of loading and inflammation on forearm bones in a rat model of upper extremity overuse. Trabecular structure in distal radius and ulna was examined in three groups of young adult rats: 1) 5% food-restricted that underwent an initial training period of 10 min/day for 5 weeks to learn the repetitive task (TRHF); 2) rats that underwent the same training before performing a high repetition high force task, 2 hours/day for 12 weeks (HRHF); and 3) food-restricted only (FRC). Subsets were treated with oral ibuprofen (IBU). TRHF rats had increased trabecular bone volume and numbers, osteoblasts, and serum osteocalcin, indicative of bone adaptation. HRHF rats had constant muscle pulling forces, showed limited signs of bone adaptation, but many signs of bone resorption, including decreased trabecular bone volume and bone mineral density, increased osteoclasts and bone inflammatory cytokines, and reduced median nerve conduction velocity (15%). HRHF+IBU rats showed no trabecular resorptive changes, no increased osteoclasts or bone inflammatory cytokines, no nerve inflammation, preserved nerve conduction, and increased muscle voluntary pulling forces. Ibuprofen treatment preserved trabecular bone quality by reducing osteoclasts and bone inflammatory cytokines, and improving muscle pulling forces on bones as a result of reduced nerve inflammation.
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Details
- Title
- Bone Loss from High Repetitive High Force Loading is Prevented by Ibuprofen Treatment
- Creators
- Nisha X. Jain - Department of Anatomy and Cell Biology, Temple University School of Medicine, 3500 North Broad St., Philadelphia, PA 19140 College of Health Professions, Pacific University, 190 SE 8th Avenue, Hillsboro, OR 97123 Department of Neurobiology and Anatomy, Drexel University College of Medicine, 2900 Queen Lane, Philadelphia, PA 19129 Department of Rehabilitation and Movement Sciences, Rutgers School of Health Related Professions, 40 E. Laurel Rd, Stratford, NJ, 08084 Department of Physical Therapy, Thomas Jefferson University, Philadelphia, PA, 19107,USAAnn E. Barr-Gillespie - Department of Anatomy and Cell Biology, Temple University School of Medicine, 3500 North Broad St., Philadelphia, PA 19140 College of Health Professions, Pacific University, 190 SE 8th Avenue, Hillsboro, OR 97123 Department of Neurobiology and Anatomy, Drexel University College of Medicine, 2900 Queen Lane, Philadelphia, PA 19129 Department of Rehabilitation and Movement Sciences, Rutgers School of Health Related Professions, 40 E. Laurel Rd, Stratford, NJ, 08084 Department of Physical Therapy, Thomas Jefferson University, Philadelphia, PA, 19107,USABrian D. Clark - Drexel UniversityDavid M. Kietrys - Department of Anatomy and Cell Biology, Temple University School of Medicine, 3500 North Broad St., Philadelphia, PA 19140 College of Health Professions, Pacific University, 190 SE 8th Avenue, Hillsboro, OR 97123 Department of Neurobiology and Anatomy, Drexel University College of Medicine, 2900 Queen Lane, Philadelphia, PA 19129 Department of Rehabilitation and Movement Sciences, Rutgers School of Health Related Professions, 40 E. Laurel Rd, Stratford, NJ, 08084 Department of Physical Therapy, Thomas Jefferson University, Philadelphia, PA, 19107,USAChristine K. Wade - Department of Anatomy and Cell Biology, Temple University School of Medicine, 3500 North Broad St., Philadelphia, PA 19140 College of Health Professions, Pacific University, 190 SE 8th Avenue, Hillsboro, OR 97123 Department of Neurobiology and Anatomy, Drexel University College of Medicine, 2900 Queen Lane, Philadelphia, PA 19129 Department of Rehabilitation and Movement Sciences, Rutgers School of Health Related Professions, 40 E. Laurel Rd, Stratford, NJ, 08084 Department of Physical Therapy, Thomas Jefferson University, Philadelphia, PA, 19107,USAJudith Litvin - Department of Anatomy and Cell Biology, Temple University School of Medicine, 3500 North Broad St., Philadelphia, PA 19140 College of Health Professions, Pacific University, 190 SE 8th Avenue, Hillsboro, OR 97123 Department of Neurobiology and Anatomy, Drexel University College of Medicine, 2900 Queen Lane, Philadelphia, PA 19129 Department of Rehabilitation and Movement Sciences, Rutgers School of Health Related Professions, 40 E. Laurel Rd, Stratford, NJ, 08084 Department of Physical Therapy, Thomas Jefferson University, Philadelphia, PA, 19107,USASteven N. Popoff - Department of Anatomy and Cell Biology, Temple University School of Medicine, 3500 North Broad St., Philadelphia, PA 19140 College of Health Professions, Pacific University, 190 SE 8th Avenue, Hillsboro, OR 97123 Department of Neurobiology and Anatomy, Drexel University College of Medicine, 2900 Queen Lane, Philadelphia, PA 19129 Department of Rehabilitation and Movement Sciences, Rutgers School of Health Related Professions, 40 E. Laurel Rd, Stratford, NJ, 08084 Department of Physical Therapy, Thomas Jefferson University, Philadelphia, PA, 19107,USAMary F. Barbe - Department of Anatomy and Cell Biology, Temple University School of Medicine, 3500 North Broad St., Philadelphia, PA 19140 College of Health Professions, Pacific University, 190 SE 8th Avenue, Hillsboro, OR 97123 Department of Neurobiology and Anatomy, Drexel University College of Medicine, 2900 Queen Lane, Philadelphia, PA 19129 Department of Rehabilitation and Movement Sciences, Rutgers School of Health Related Professions, 40 E. Laurel Rd, Stratford, NJ, 08084 Department of Physical Therapy, Thomas Jefferson University, Philadelphia, PA, 19107,USA
- Publication Details
- Journal of musculoskeletal & neuronal interactions, v 14(1)
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Neurobiology and Anatomy
- Web of Science ID
- WOS:000334579300009
- Scopus ID
- 2-s2.0-84895419444
- Other Identifier
- 991019169411804721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Neurosciences
- Physiology