Journal article
Bone disease in organ transplant patients: pathogenesis and management
Postgraduate medicine, v 124(3)
May 2012
PMID: 22691902
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Bone disease is common in recipients of kidney, heart, lung, liver, and bone marrow transplants, and causes debilitating complications, such as osteoporosis, osteonecrosis, bone pain, and fractures. The frequency of fractures ranges from 6% to 45% for kidney transplant recipients to 22% to 42% for heart, lung, and liver transplant recipients. Bone disease in transplant patients is the sum of complex mechanisms that involve both preexisting bone disease before transplant and post-transplant bone loss due to the effects of immunosuppressive medications. Evaluation of bone disease should preferably start before the transplant or in the early post-transplant period and include assessment of bone mineral density and other metabolic factors that influence bone health. This requires close coordination between the primary care physician and transplant team. Patients should be stratified based on their fracture risk. Prevention and treatment include risk factor reduction, antiresorptive medications, such as bisphosphonates and calcitonin, calcitriol, and/or gonadal hormone replacement. A steroid-avoidance protocol may be considered.
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Details
- Title
- Bone disease in organ transplant patients: pathogenesis and management
- Creators
- Veeraish Chauhan - Hahnemann University HospitalKarthik M Ranganna - Hahnemann University HospitalNishtha Chauhan - Manipal Academy of Higher EducationMegha Vaid - Thomas Jefferson UniversityEllie Kelepouris - Hahnemann University Hospital
- Publication Details
- Postgraduate medicine, v 124(3)
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Medicine (Graduate)
- Web of Science ID
- WOS:000307103800010
- Scopus ID
- 2-s2.0-84867868892
- Other Identifier
- 991019169647904721
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- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Endocrinology & Metabolism