Journal article
Bone marrow derived macrophages have polyamine and ectoenzyme phenotypes distinct from resident macrophages
Life sciences (1973), v 42(20), pp 2019-2027
1988
PMID: 2835568
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Several prototype macrophage (MO) populations were compared for differences in ectoenzyme phenotype and polyamine content. Resident peritoneal MO and
Corynebacterium parvum
(CP)-activated peritoneal MO expressed unique ectoenzyme phenotypes, while bone marrow derived MO (BMDMO), obtained from stem cells after 7 days in culture with colony stimulating factor, and thioglycollate (TG)-elicited peritoneal MO exhibited a similar ectoenzyme phenotype. All of the MO populations, however, differed in polyamine accumulation patterns. These results suggest that ectoenzyme phenotypes do not serve as completely selective markers of MO differentiation. Moreover, BMDMO do not resemble steady state tissue peritoneal MO but appear to resemble inflammatory MO in several respects. Therefore activated BMDMO do not appear to provide an accurate model system for their continued use in studies to characterize the development of resident tissue MO.
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Details
- Title
- Bone marrow derived macrophages have polyamine and ectoenzyme phenotypes distinct from resident macrophages
- Creators
- Walla L. Dempsey - Drexel UniversityPatrick Hwu - Melanoma Medical OncologyDiane Haddock Russell - University of ArizonaPage S. Morahan - Drexel University
- Publication Details
- Life sciences (1973), v 42(20), pp 2019-2027
- Publisher
- Elsevier
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- [Retired Faculty]
- Web of Science ID
- WOS:A1988N025300014
- Scopus ID
- 2-s2.0-0023672354
- Other Identifier
- 991019184305404721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Medicine, Research & Experimental
- Pharmacology & Pharmacy