Journal article
Bone-metastatic potential of human prostate cancer cells correlates with Akt/PKB activation by α platelet-derived growth factor receptor
Oncogene, v 24(45), pp 6848-6854
13 Oct 2005
PMID: 16007172
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Prostate adenocarcinoma metastasizes to the skeleton more frequently than any other organ. An underlying cause of this phenomenon may be the ability of bone-produced factors to specifically select disseminated prostate cancer cells that are susceptible to their trophic effects. Platelet-derived growth factor (PDGF), a potent mitogen for both normal and tumor cells, is produced in several tissues including bone, where it is synthesized by both osteoblasts and osteoclasts. Here, we show that PDGF causes a significantly stronger activation of the Akt/PKB survival pathway in bone-metastatic prostate cancer cells compared to nonmetastatic cells. Normal prostate epithelial cells and DU-145 prostate cells, originally derived from a brain metastasis, are not responsive to PDGF. In contrast, epidermal growth factor stimulates Akt to the same extent in all prostate cells tested. This difference in PDGF responsiveness depends on the higher expression of α-PDGFR in bone-metastatic compared to nonmetastatic prostate cells and the lack of α-PDGFR expression in normal and metastatic prostate cells derived from tissues other than bone. Thus, α-PDGFR expression might identify prostate cancer cells with the highest propensity to metastasize to the skeleton.
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Details
- Title
- Bone-metastatic potential of human prostate cancer cells correlates with Akt/PKB activation by α platelet-derived growth factor receptor
- Creators
- Nathan G Dolloff - Department of Pharmacology and Physiology, Drexel University College of Medicine, Philadelphia, PA 19102, USAShannon S Shulby - Department of Pharmacology and Physiology, Drexel University College of Medicine, Philadelphia, PA 19102, USAAutumn V Nelson - Department of Pharmacology and Physiology, Drexel University College of Medicine, Philadelphia, PA 19102, USAMark E Stearns - Department of Pathology, Drexel University College of Medicine, Philadelphia, PA 19102, USAGregg J Johannes - Department of Pathology, Drexel University College of Medicine, Philadelphia, PA 19102, USAJeff D Thomas - Department of Pathology, Drexel University College of Medicine, Philadelphia, PA 19102, USAOlimpia Meucci - Department of Pharmacology and Physiology, Drexel University College of Medicine, Philadelphia, PA 19102, USAAlessandro Fatatis - Department of Pharmacology and Physiology, Drexel University College of Medicine, Philadelphia, PA 19102, USA
- Publication Details
- Oncogene, v 24(45), pp 6848-6854
- Publisher
- Springer Nature
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Pharmacology and Physiology
- Web of Science ID
- WOS:000232527800013
- Scopus ID
- 2-s2.0-27144473338
- Other Identifier
- 991014877836704721
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InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Web of Science research areas
- Biochemistry & Molecular Biology
- Cell Biology
- Genetics & Heredity
- Oncology