Journal article
Braided multi-electrode probes: mechanical compliance characteristics and recordings from spinal cords
Journal of neural engineering, v 10(4), pp 045001-045001
31 May 2013
PMID: 23723128
Abstract
Objective. To test a novel braided multi-electrode probe design with compliance exceeding that of a 50 µm microwire, thus reducing micromotion- and macromotion-induced tissue stress. Approach. We use up to 24 ultra-fine wires interwoven into a tubular braid to obtain a highly flexible multi-electrode probe. The tether-portion wires are simply non-braided extensions of the braid structure, allowing the microprobe to follow gross neural tissue movements. Mechanical calculation and direct measurements evaluated bending stiffness and axial compression forces in the probe and tether system. These were compared to 50 µm nichrome microwire standards. Recording tests were performed in decerebrate animals. Main results. Mechanical bending tests on braids comprising 9.6 or 12.7 µm nichrome wires showed that implants (braided portions) had 4 to 21 times better mechanical compliance than a single 50 µm wire and non-braided tethers were 6 to 96 times better. Braided microprobes yielded robust neural recordings from animals' spinal cords throughout cord motions. Significance. Microwire electrode arrays that can record and withstand tissue micro- and macromotion of spinal cord tissues are demonstrated. This technology may provide a stable chronic neural interface into spinal cords of freely moving animals, is extensible to various applications, and may reduce mechanical tissue stress.
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Details
- Title
- Braided multi-electrode probes: mechanical compliance characteristics and recordings from spinal cords
- Creators
- Taegyo Kim - Drexel University School of Biomedical Engineering, Science and Health System, Philadelphia, PA, USAAlmut Branner - Drexel University College of Medicine Neurobiology&Anatomy Department, Philadelphia, PA, USATanuj Gulati - Drexel University College of Medicine Neurobiology&Anatomy Department, Philadelphia, PA, USASimon F Giszter - Drexel University College of Medicine Neurobiology&Anatomy Department, Philadelphia, PA, USA
- Publication Details
- Journal of neural engineering, v 10(4), pp 045001-045001
- Publisher
- IOP Publishing
- Number of pages
- 10
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Neurobiology and Anatomy
- Web of Science ID
- WOS:000322221600003
- Scopus ID
- 2-s2.0-84883181510
- Other Identifier
- 991014877716104721
InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Web of Science research areas
- Engineering, Biomedical
- Neurosciences