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Published, Version of Record (VoR)CC BY V4.0, Open
Journal article
Brain Connectometry Changes in Space Travelers After Long-Duration Spaceflight
Frontiers in neural circuits, v 16, pp 815838-815838
2022
PMID: 35250494
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Humans undergo extreme physiological changes when subjected to long periods of weightlessness, and as we continue to become a space-faring species, it is imperative that we fully understand the physiological changes that occur in the human body, including the brain. In this study, we present findings of brain structural changes associated with long-duration spaceflight based on diffusion magnetic resonance imaging (dMRI) data. Twelve cosmonauts who spent an average of six months aboard the International Space Station (ISS) were scanned in an MRI scanner pre-flight, ten days after flight, and at a follow-up time point seven months after flight. We performed differential tractography, a technique that confines white matter fiber tracking to voxels showing microstructural changes. We found significant microstructural changes in several large white matter tracts, such as the corpus callosum, arcuate fasciculus, corticospinal, corticostriatal, and cerebellar tracts. This is the first paper to use fiber tractography to investigate which specific tracts exhibit structural changes after long-duration spaceflight and may direct future research to investigate brain functional and behavioral changes associated with these white matter pathways.
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Details
- Title
- Brain Connectometry Changes in Space Travelers After Long-Duration Spaceflight
- Creators
- Andrei Doroshin - Drexel UniversitySteven Jillings - University of AntwerpBen Jeurissen - University of AntwerpElena Tomilovskaya - State Scientific Center of the Russian Federation - Institute for Biomedical Problem, Russian Academy of Sciences, Moscow, RussiaEkaterina Pechenkova - Laboratory for Cognitive Research, HSE University, Moscow, RussiaInna Nosikova - Institute of Biomedical ProblemsAlena Rumshiskaya - Radiology Department, National Medical Research Treatment and Rehabilitation Centre of the Ministry of Health of Russia, Moscow, RussiaLiudmila Litvinova - Radiology Department, National Medical Research Treatment and Rehabilitation Centre of the Ministry of Health of Russia, Moscow, RussiaIlya Rukavishnikov - Institute of Biomedical ProblemsChloë De Laet - University of AntwerpCatho Schoenmaekers - University of AntwerpJan Sijbers - University of AntwerpSteven Laureys - University of LiègeVictor Petrovichev - Radiology Department, National Medical Research Treatment and Rehabilitation Centre of the Ministry of Health of Russia, Moscow, RussiaAngelique Van Ombergen - University of AntwerpJitka Annen - University of LiègeStefan Sunaert - KU LeuvenPaul M Parizel - Royal Perth HospitalValentin Sinitsyn - Lomonosov Moscow State UniversityPeter Zu Eulenburg - Ludwig-Maximilians-Universität MünchenKarol Osipowicz - Drexel UniversityFloris L Wuyts - University of Antwerp
- Publication Details
- Frontiers in neural circuits, v 16, pp 815838-815838
- Publisher
- Frontiers
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Psychological and Brain Sciences (Psychology)
- Web of Science ID
- WOS:000765545700001
- Scopus ID
- 2-s2.0-85125832222
- Other Identifier
- 991019168161104721
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- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Neurosciences