Journal article
Brain Trauma in Aged Transgenic Mice Induces Regression of Established Aβ Deposits
Experimental neurology, v 163(1)
May 2000
PMID: 10785464
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Traumatic brain injury (TBI) increases susceptibility to Alzheimer's disease (AD), but it is not known if TBI affects the progression of AD. To address this question, we studied the neuropathological consequences of TBI in transgenic (TG) mice with a mutant human Aβ precursor protein (APP) mini-gene driven by a platelet-derived (PD) growth factor promoter resulting in overexpression of mutant APP (V717F), elevated brain Aβ levels, and AD-like amyloidosis. Since brain Aβ deposits first appear in 6-month-old TG (PDAPP) mice and accumulate with age, 2-year-old PDAPP and wild-type (WT) mice were subjected to controlled cortical impact (CCI) TBI or sham treatment. At 1, 9, and 16 weeks after TBI, neuron loss, gliosis, and atrophy were most prominent near the CCI site in PDAPP and WT mice. However, there also was a remarkable regression in the Aβ amyloid plaque burden in the hippocampus ipsilateral to TBI compared to the contralateral hippocampus of the PDAPP mice by 16 weeks postinjury. Thus, these data suggest that previously accumulated Aβ plaques resulting from progressive amyloidosis in the AD brain also may be reversible.
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Details
- Title
- Brain Trauma in Aged Transgenic Mice Induces Regression of Established Aβ Deposits
- Creators
- Yasushi Nakagawa - Kyushu UniversityLee Reed - University of PennsylvaniaMichio Nakamura - University of PennsylvaniaTracy K. McIntosh - University of PennsylvaniaDouglas H. Smith - University of PennsylvaniaKathryn E. Saatman - University of PennsylvaniaRamesh Raghupathi - University of PennsylvaniaJames Clemens - Eli LillyTakaomi C. Saido - RIKEN Center for Brain ScienceVirginia M.-Y. Lee - University of PennsylvaniaJohn Q. Trojanowski - University of Pennsylvania
- Publication Details
- Experimental neurology, v 163(1)
- Publisher
- Elsevier
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Neurobiology and Anatomy
- Web of Science ID
- WOS:000087006500027
- Scopus ID
- 2-s2.0-0034068261
- Other Identifier
- 991019222873904721
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- Collaboration types
- Industry collaboration
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Neurosciences