Journal article
Brain-derived neurotrophic factor (BDNF) epigenomic modifications and brain-related phenotypes in humans: A systematic review
Neuroscience and biobehavioral reviews, v 147, pp 105078-105078
01 Apr 2023
PMID: 36764636
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Epigenomic modifications of the brain-derived neurotrophic factor (BDNF) gene have been postulated to underlie the pathogenesis of neurodevelopmental, psychiatric, and neurological conditions. This systematic review summarizes current evidence investigating the association of BDNF epigenomic modifications (DNA methylation, non-coding RNA, histone modifications) with brain-related phenotypes in humans. A novel contribution is our creation of an open access web-based application, the BDNF DNA Methylation Map, to interactively visualize specific positions of CpG sites investigated across all studies for which relevant data were available. Our literature search of four databases through September 27, 2021 returned 1701 articles, of which 153 met inclusion criteria. Our review revealed exceptional heterogeneity in methodological approaches, hindering the identification of clear patterns of robust and/or replicated results. We summarize key findings and provide recommendations for future epigenomic research. The existing literature appears to remain in its infancy and requires additional rigorous research to fulfill its potential to explain BDNF-linked risk for brain-related conditions and improve our understanding of the molecular mechanisms underlying their pathogenesis.
•153 articles examined BDNF epigenomic modifications and brain-related phenotypes.•Novel BDNF DNA Methylation Map allows users to interactively visualize CpGs.•BDNF epigenomics lack robust/replicated results due to methodological heterogeneity.
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Details
- Title
- Brain-derived neurotrophic factor (BDNF) epigenomic modifications and brain-related phenotypes in humans: A systematic review
- Creators
- Amery Treble-Barna - University of PittsburghLacey W. Heinsberg - University of PittsburghZachary Stec - University of PittsburghStephen Breazeale - University of PittsburghTara S. Davis - University of PittsburghAboli A. Kesbhat - Drexel UniversityAnsuman Chattopadhyay - University of PittsburghHelena M. VonVille - University of PittsburghAndrea M. Ketchum - University of PittsburghKeith Owen Yeates - University of CalgaryPatrick M. Kochanek - University of PittsburghDaniel E. Weeks - University of PittsburghYvette P. Conley - University of Pittsburgh
- Publication Details
- Neuroscience and biobehavioral reviews, v 147, pp 105078-105078
- Publisher
- Elsevier Ltd
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- College of Medicine
- Web of Science ID
- WOS:000944679700001
- Scopus ID
- 2-s2.0-85148366274
- Other Identifier
- 991022207059204721
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- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Behavioral Sciences
- Neurosciences