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Journal article
Brain glucose metabolism in patients with newly diagnosed multiple myeloma significantly decreases after high-dose chemotherapy followed by autologous stem cell transplantation
Nuclear medicine communications, v 41(3), pp 288-293
Mar 2020
PMID: 31895757
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
The aim of this study was to compare the effect of intensive therapy [consisting of high-dose chemotherapy followed by autologous stem cell transplantation (HDC/ASCT)] and conventional standard-dose chemotherapy (CDC) on brain FDG uptake, as an indicator of glucose metabolism, in multiple myeloma patients.
Twenty-four patients with newly diagnosed multiple myeloma were included. Sixteen patients received HDC/ASCT, including bortezomib-based induction therapy, and eight patients received CDC. F-fluorodeoxyglucose (FDG)-PET/computed tomography (CT) was performed 1 and 3 hours following tracer administration before and after the treatment. The manual segmentation of supratentorial and cerebellum of each patient was performed by two independent observers. The data were expressed as global mean standardized uptake values (GSUVmean). Wilcoxon signed-rank test was used to compare changes from before to after treatment.
A significant decrease in the GSUVmean of supratentorial brain and cerebellum was observed after treatment in the patients who received HDC/ASCT (1 hour scans: 7.03 ± 1.18 vs. 6.56 ± 0.94; P = 0.03 and 7.01 ± 1.08 vs. 6.34 ± 0.93; P = 0.01, respectively). GSUVmean changes in the patients who received CDC were not significantly different after treatment (1 hour scans: 6.47 ± 1.16 vs. 6.21 ± 0.91; P = 0.40 and 6.30 ± 1.21 vs. 6.09 ± 0.86; P = 0.62, respectively). The same findings were observed for 3 hours scans. A high level of agreement was observed between two operators.
Multiple myeloma patients who received HDC/ASCT demonstrated a significant decrease in FDG uptake in the supratentorial brain and cerebellum, while patients who received CDC did not demonstrate significant changes in the brain FDG uptake.
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Details
- Title
- Brain glucose metabolism in patients with newly diagnosed multiple myeloma significantly decreases after high-dose chemotherapy followed by autologous stem cell transplantation
- Creators
- Sara Pourhassan Shamchi - University of PennsylvaniaMahdi Zirakchian Zadeh - Children's Hospital of PhiladelphiaBrian Østergaard - University of Southern DenmarkJennifer Kim - University of PennsylvaniaWilliam Y Raynor - University of PennsylvaniaMohsen Khosravi - University of PennsylvaniaRaheleh Taghvaei - University of PennsylvaniaAnne L Nielsen - Odense University HospitalOke Gerke - Odense University HospitalThomas J Werner - University of PennsylvaniaPaw Holdgaard - Vejle SygehusNiels Abildgaard - University of Southern DenmarkMona-Elisabeth Revheim - Oslo University HospitalPoul Flemming Høilund-Carlsen - Odense University HospitalAbass Alavi - University of Pennsylvania
- Publication Details
- Nuclear medicine communications, v 41(3), pp 288-293
- Publisher
- Lippincott
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Radiology (Radiologic Sciences)
- Web of Science ID
- WOS:000531348300016
- Scopus ID
- 2-s2.0-85083874084
- Other Identifier
- 991019350580604721
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- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Radiology, Nuclear Medicine & Medical Imaging