Journal article
Brain uptake of thallium-201 from the cerebrospinal fluid compartment
The Journal of nuclear medicine (1978), v 34(1)
Jan 1993
PMID: 8418278
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Abstract
The present report elucidates the movement of 201Tl through the cerebrospinal fluid compartment and its subsequent uptake by normal brain. Autoradiographic studies of rat brain, after stereotaxic 201Tl injection into either the lateral or fourth ventricle, reveal that 201Tl moves freely through the cerebrospinal and extracellular fluid compartments. Subsequent to lateral ventricular injection, central thalamic and specific hypothalamic nuclei are heavily labeled. Densely labeled mesencephalic nuclei include the periaqueductal grey and oculomotor nuclear complex. Labeling of giant cells within the vestibular complex is suggestive of neuronal uptake. Major fiber tracts are devoid of label confirming that 201Tl uptake does not occur in white matter. Most labeling following fourth ventricle injection occurs within the caudal medulla and cervical spinal grey. Our findings suggest that 201Tl uptake by normal brain from the cerebrospinal fluid occurs as a function of thallium concentration and neuronal activity.
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Details
- Title
- Brain uptake of thallium-201 from the cerebrospinal fluid compartment
- Creators
- J A Rubertone - Department of Radiation Oncology and Nuclear Medicine, Hahnemann University School of Medicine, Philadelphia, PA 19102-1192D V WooJ G EmrichL W Brady
- Publication Details
- The Journal of nuclear medicine (1978), v 34(1)
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Radiation Oncology (and Nuclear Medicine); Medical College of Pennsylvania and Hahnemann University (1993-1996, 1998-2002); [Retired Faculty]; Physical Therapy (and Rehabilitation Sciences)
- Web of Science ID
- WOS:A1993KE71500019
- Scopus ID
- 2-s2.0-0027463976
- Other Identifier
- 991019184076504721
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InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Web of Science research areas
- Radiology, Nuclear Medicine & Medical Imaging