Journal article
Brainstem respiratory networks: building blocks and microcircuits
Trends in neurosciences (Regular ed.), v 36(3), pp 152-162
Mar 2013
PMID: 23254296
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Breathing movements in mammals are driven by rhythmic neural activity generated within spatially and functionally organized brainstem neural circuits comprising the respiratory central pattern generator (CPG). This rhythmic activity provides homeostatic regulation of gases in blood and tissues and integrates breathing with other motor acts. We review new insights into the spatial–functional organization of key neural microcircuits of this CPG from recent multidisciplinary experimental and computational studies. The emerging view is that the microcircuit organization within the CPG allows the generation of multiple rhythmic breathing patterns and adaptive switching between them, depending on physiological or pathophysiological conditions. These insights open the possibility for site- and mechanism-specific interventions to treat various disorders of the neural control of breathing.
Metrics
Details
- Title
- Brainstem respiratory networks: building blocks and microcircuits
- Creators
- Jeffrey C Smith - Cellular and Systems Neurobiology Section, National Institute of Neurological Disorders and Stroke (NINDS), National Institutes of Health (NIH), Bethesda, MD, USAAna P.L Abdala - School of Physiology and Pharmacology, Bristol Heart Institute, Medical Sciences Building, University of Bristol, Bristol, UKAnke Borgmann - Cellular and Systems Neurobiology Section, National Institute of Neurological Disorders and Stroke (NINDS), National Institutes of Health (NIH), Bethesda, MD, USAIlya A Rybak - Department of Anatomy and Neurobiology, Drexel University College of Medicine, Philadelphia, PA, USAJulian F.R Paton - School of Physiology and Pharmacology, Bristol Heart Institute, Medical Sciences Building, University of Bristol, Bristol, UK
- Publication Details
- Trends in neurosciences (Regular ed.), v 36(3), pp 152-162
- Publisher
- Elsevier
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Neurobiology and Anatomy
- Web of Science ID
- WOS:000316710400006
- Scopus ID
- 2-s2.0-84875261242
- Other Identifier
- 991014877797404721
UN Sustainable Development Goals (SDGs)
This publication has contributed to the advancement of the following goals:
InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Neurosciences