Journal article
Brainstem tegmental necrosis and olivary hypoplasia: raising awareness of a rare neuropathologic correlate of congenital apnea
Seminars in pediatric neurology, v 21(2), pp 177-183
Jun 2014
PMID: 25149959
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
This case study describes an instance of death in an early term female newborn with congenital apnea in the clinical setting of multiple congenital anomalies (retrognathia, posteriorly rotated ears, camptodactyly, and arthrogryposis) and prenatal history of polyhydramnios. Postmortem neuropathologic findings were significant for tegmental necrosis in the caudal pons and medulla characterized by a coalescence of microcalcifications accompanied by neuronal loss, axonal spheroids, gliosis, and a concomitant hypoplasia of the inferior olives. This report raises awareness of the rare lethal entity of brainstem tegmental necrosis and olivary hypoplasia and its nosological relationship to the Möbius syndrome in the context of differential diagnosis of congenital apnea owing to central respiratory dysfunction.
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Details
- Title
- Brainstem tegmental necrosis and olivary hypoplasia: raising awareness of a rare neuropathologic correlate of congenital apnea
- Creators
- Christos D Katsetos - St. Christopher's Hospital for ChildrenCarol E Anderson - St. Christopher's Hospital for ChildrenMiguel A Guzman - St. Christopher's Hospital for ChildrenJudy Mae Pascasio - St. Christopher's Hospital for ChildrenJean-Pierre de Chadarévian - St. Christopher's Hospital for ChildrenAgustin Legido - St. Christopher's Hospital for Children
- Publication Details
- Seminars in pediatric neurology, v 21(2), pp 177-183
- Publisher
- Elsevier
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Pediatrics
- Web of Science ID
- WOS:000341334400038
- Scopus ID
- 2-s2.0-84906350649
- Other Identifier
- 991019169163204721
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InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Web of Science research areas
- Clinical Neurology
- Pediatrics